A New Destruxin as Inhibitor of Vacuolar-Type H super(+)-ATPase of Saccharomyces cerevisiae

In the course of our screening efforts to discover small molecules as selective inhibitors of vacuolar-type H super(+)-ATPase of Saccharomyces cerevisiae, we have identified eight active destruxins, 1-8, from the fungus Metarhizium anisopliae. The structures were elucidated by extensive 1D-and 2D-NM...

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Bibliographic Details
Published in:Chemistry & biodiversity 2005-01, Vol.2 (1), p.123-130
Main Authors: Albarran, Maria, Alfonso, Espada, Alfonso, Rivera-Sagredo, Emilio, Diez, Hueso-Rodriguez, Juan
Format: Article
Language:English
Subjects:
Metarhizium anisopliae
Saccharomyces cerevisiae
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Summary:In the course of our screening efforts to discover small molecules as selective inhibitors of vacuolar-type H super(+)-ATPase of Saccharomyces cerevisiae, we have identified eight active destruxins, 1-8, from the fungus Metarhizium anisopliae. The structures were elucidated by extensive 1D-and 2D-NMR spectroscopy, and MS spectrometry. One of these compounds, 8, a regioisomer of chlorohydrin destruxin E (7), is a new destruxin.
ISSN:1612-1872
1612-1880
DOI:10.1002/cbdv.200490163