Serum antioxidant enzymes activities and oxidative stress levels in patients with acute ischemic stroke: influence on neurological status and outcome

Summary Background Oxidative stress is well believed to play a role in the pathogenesis of acute ischemic stroke. Reports on antioxidant enzyme activities in patients with stroke are conflicting. Therefore, the aim of this study was to investigate serum antioxidant enzyme activities and oxidative st...

Full description

Saved in:
Bibliographic Details
Published in:Wiener Klinische Wochenschrift 2016-03, Vol.128 (5-6), p.169-174
Main Authors: Milanlioglu, Aysel, Aslan, Mehmet, Ozkol, Halil, Çilingir, Vedat, Nuri Aydın, Mehmet, Karadas, Sevdegül
Format: Article
Language:English
Subjects:
Acute Disease
Antioxidants - analysis
Biomarkers - blood
Comorbidity
Endocrinology
Enzyme Activation
Female
Gastroenterology
Humans
Internal Medicine
Male
Malondialdehyde - blood
Medicine
Medicine & Public Health
Middle Aged
Nervous System Diseases - blood
Nervous System Diseases - enzymology
Nervous System Diseases - epidemiology
Original Article
Oxidative Stress
Oxidoreductases - blood
Pneumology/Respiratory System
Prevalence
Prognosis
Reactive Oxygen Species - blood
Reproducibility of Results
Risk Factors
Sensitivity and Specificity
Stroke - blood
Stroke - enzymology
Stroke - epidemiology
Turkey - epidemiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Summary Background Oxidative stress is well believed to play a role in the pathogenesis of acute ischemic stroke. Reports on antioxidant enzyme activities in patients with stroke are conflicting. Therefore, the aim of this study was to investigate serum antioxidant enzyme activities and oxidative stress levels in patients with acute ischemic stroke within 1st, 5th, and 21st day after stroke onset and also the relationship between these results and the clinical status of patients. Methods The current study comprised 45 patients with acute ischemic stroke and 30 healthy controls. Serum malondialdehyde (MDA) levels, superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase activities were measured spectrophotometrically. Results Serum MDA levels were significantly higher in acute ischemic stroke patients within 24 h after stroke onset than controls ( p  
ISSN:0043-5325
1613-7671
DOI:10.1007/s00508-015-0742-6