Sarcopenia, but not visceral fat amount, is a risk factor of postoperative complications after major hepatectomy

Background Major hepatectomy is associated with significant morbidity and mortality rates, particularly in patients aged more than 70 years. This study assessed whether physical indicators, such as sarcopenia and visceral fat amount, could predict morbidity and mortality after major hepatectomy. Met...

Full description

Saved in:
Bibliographic Details
Published in:International journal of clinical oncology 2016-04, Vol.21 (2), p.310-319
Main Authors: Higashi, Takaaki, Hayashi, Hiromitsu, Taki, Katsunobu, Sakamoto, Keita, Kuroki, Hideyuki, Nitta, Hidetoshi, Hashimoto, Daisuke, Chikamoto, Akira, Beppu, Toru, Baba, Hideo
Format: Article
Language:English
Subjects:
Aged
Body fat
Cancer Research
Female
Hepatectomy - adverse effects
Hepatectomy - mortality
Humans
Intra-Abdominal Fat - diagnostic imaging
Liver cancer
Lumbosacral Region - diagnostic imaging
Male
Medicine
Medicine & Public Health
Middle Aged
Muscle, Skeletal - diagnostic imaging
Older people
Oncology
Original Article
Risk Factors
Sarcopenia - complications
Sarcopenia - diagnostic imaging
Studies
Surgical Oncology
Tomography, X-Ray Computed
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background Major hepatectomy is associated with significant morbidity and mortality rates, particularly in patients aged more than 70 years. This study assessed whether physical indicators, such as sarcopenia and visceral fat amount, could predict morbidity and mortality after major hepatectomy. Methods The study enrolled 144 patients who underwent curative major hepatectomy. Skeletal muscle and visceral fat amount at the third lumbar vertebra (L3) in the inferior direction were quantified using enhanced computed tomography scans. The patients were divided into two subgroups, with and without sarcopenia, based on median skeletal muscle mass in men and women (43.2 cm 2 /m 2 in men; 35.3 cm 2 /m 2 in women). Results The study included 108 men and 36 women, with median skeletal muscle tissue of 43.2 and 35.3 cm 2 /m 2 , respectively. The mortality rate was significantly higher in patients with than without sarcopenia [seven cases (9.7 %), one case (1.4 %), respectively; P  = 0.021], whereas liver-related morbidity and mortality rates were similar. In patients aged >70 years, the morbidity, liver dysfunction-related morbidity, and mortality rates were significantly higher in patients with than without sarcopenia ( P  
ISSN:1341-9625
1437-7772
DOI:10.1007/s10147-015-0898-0