Monodisperse Cylindrical Micelles and Block Comicelles of Controlled Length in Aqueous Media

Cylindrical block copolymer micelles have shown considerable promise in various fields of biomedical research. However, unlike spherical micelles and vesicles, control over their dimensions in biologically relevant solvents has posed a key challenge that potentially limits in depth studies and their...

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Bibliographic Details
Published in:Journal of the American Chemical Society 2016-04, Vol.138 (13), p.4484-4493
Main Authors: Nazemi, Ali, Boott, Charlotte E, Lunn, David J, Gwyther, Jessica, Hayward, Dominic W, Richardson, Robert M, Winnik, Mitchell A, Manners, Ian
Format: Article
Language:English
Subjects:
Epoxy Compounds - chemistry
Micelles
Models, Molecular
Polyethylene Glycols - chemistry
Polymers - chemistry
Polystyrenes - chemistry
Polyvinyls - chemistry
Pyridines - chemistry
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Summary:Cylindrical block copolymer micelles have shown considerable promise in various fields of biomedical research. However, unlike spherical micelles and vesicles, control over their dimensions in biologically relevant solvents has posed a key challenge that potentially limits in depth studies and their optimization for applications. Here, we report the preparation of cylindrical micelles of length in the wide range of 70 nm to 1.10 μm in aqueous media with narrow length distributions (length polydispersities
ISSN:0002-7863
1520-5126
DOI:10.1021/jacs.5b13416