Increased central arterial stiffness and altered cerebrovascular haemodynamic properties in South Asian older adults

South Asians (SA) suffer from a higher burden of heart disease and stroke compared with White Caucasians (CA). We hypothesized that increased arterial stiffness in older adults of SA origin would be associated with greater cerebrovascular pulsatile pressure and flow characteristics compared with CA...

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Bibliographic Details
Published in:Journal of human hypertension 2016-05, Vol.30 (5), p.309-314
Main Authors: Brar, I, Robertson, A D, Hughson, R L
Format: Article
Language:English
Subjects:
692/699
Aged
Aged, 80 and over
Aging
Ankle
Arteries
Asia, Western - ethnology
Asian Continental Ancestry Group
Blood flow
C-reactive protein
Carotid artery
Cerebral blood flow
Cerebrovascular Circulation
Cerebrovascular disease
Cerebrovascular diseases
Coronary artery disease
Cross-Sectional Studies
Doppler effect
Epidemiology
European Continental Ancestry Group
Flow velocity
Health Administration
Health aspects
Heart diseases
Hemodynamics
Hemoglobin
Humans
Male
Medicine
Medicine & Public Health
Middle Aged
Older people
original-article
Physiological aspects
Pressure
Public Health
Pulsatile Flow
Risk factors
Structure-function relationships
Ultrasound
Vascular diseases
Vascular Stiffness
Veins & arteries
Velocity
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Summary:South Asians (SA) suffer from a higher burden of heart disease and stroke compared with White Caucasians (CA). We hypothesized that increased arterial stiffness in older adults of SA origin would be associated with greater cerebrovascular pulsatile pressure and flow characteristics compared with CA older adults. Forty-four SA and CA older adults, free of known cardiovascular and cerebrovascular diseases, were assessed. Vascular ageing was characterized by brachial-ankle pulse wave velocity, carotid pulse pressure, compliance coefficient (CC) and intima-media thickness (IMT). Duplex ultrasonography of the internal carotid arteries estimated anterior cerebral blood flow (aCBF) and cerebrovascular resistance (aCVR), and transcranial Doppler ultrasound quantified middle cerebral artery blood flow velocity, resistive index (RI) and pulsatility index (PI). Fasting blood samples were collected to assess glycaemic status, lipid profile and C-reactive protein. SA had higher carotid pulse pressure and lower CC indicating stiffer arteries compared with CA. Multiple regression analyses revealed that ethnic differences in arterial stiffness were associated with glycated haemoglobin level in SA. Among SA, an inverse association was observed between carotid CC and aCVR. In turn, aCVR was associated with a steeper reduction in aCBF in SA than in CA. IMT was strongly associated with greater PI and RI ( r >0.81, P
ISSN:0950-9240
1476-5527
DOI:10.1038/jhh.2015.76