Successful Desensitization to Enfuvirtide after a Hypersensitivity Reaction in an HIV-1-Infected Man

We report a case of successful, rapid desensitization to enfuvirtide after a hypersensitivity reaction in a man with highly drug-resistant human immunodeficiency virus type 1 infection. The patient was desensitized in a monitored intensive care unit and tolerated the rapid desensitization protocol w...

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Bibliographic Details
Published in:Clinical infectious diseases 2004-11, Vol.39 (10), p.e110-e112
Main Authors: DeSimone, Joseph A., Ojha, Ambrish, Pathak, Rolee, Cohn, John
Format: Article
Language:English
Subjects:
Adult
Drug Hypersensitivity - therapy
HIV Envelope Protein gp41 - adverse effects
HIV Envelope Protein gp41 - immunology
HIV Envelope Protein gp41 - therapeutic use
HIV Fusion Inhibitors - adverse effects
HIV Fusion Inhibitors - immunology
HIV Fusion Inhibitors - therapeutic use
HIV Infections - drug therapy
HIV-1
Human immunodeficiency virus 1
Humans
Male
Peptide Fragments - adverse effects
Peptide Fragments - immunology
Peptide Fragments - therapeutic use
Remission Induction
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Summary:We report a case of successful, rapid desensitization to enfuvirtide after a hypersensitivity reaction in a man with highly drug-resistant human immunodeficiency virus type 1 infection. The patient was desensitized in a monitored intensive care unit and tolerated the rapid desensitization protocol without any serious adverse effects. This case illustrates the ability to safely desensitize patients with limited treatment options who require enfuvirtide therapy.
ISSN:1058-4838
1537-6591
DOI:10.1086/425502