Effect of Cyclopentyladenosine on Lipid Peroxidation during Focal Cerebral Ischemia

The antioxidant effect of an adenosine A 1 receptor agonist cyclopentyladenosine was studied on the model of focal cerebral ischemia. Ischemic injury of the brain was accompanied by changes in LPO processes (in the blood and brain tissue) and failure of some factors for antioxidant protection (perox...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2014-06, Vol.157 (2), p.228-230
Main Authors: Sufianova, G. Z., Sufianov, A. A., Shapkin, A. G.
Format: Article
Language:English
Subjects:
Adenosine - analogs & derivatives
Adenosine - pharmacology
Adenosine - therapeutic use
Animals
Antioxidants
Biomedical and Life Sciences
Biomedicine
Brain Ischemia - drug therapy
Brain Ischemia - metabolism
Cell Biology
Cerebral ischemia
Internal Medicine
Laboratory Medicine
Lipid peroxidation
Lipid Peroxidation - drug effects
Male
Metabolites
Neuroprotective Agents - pharmacology
Neuroprotective Agents - therapeutic use
Pathology
Rats
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Summary:The antioxidant effect of an adenosine A 1 receptor agonist cyclopentyladenosine was studied on the model of focal cerebral ischemia. Ischemic injury of the brain was accompanied by changes in LPO processes (in the blood and brain tissue) and failure of some factors for antioxidant protection (peroxidase and catalase) that inactivate reactive metabolites. Changes in the ratio between LPO and antioxidant protection were less pronounced after treatment with cyclopentyladenosine.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-014-2531-z