Respiratory allergies in childhood: Recent advances and future challenges

The burden of allergic airway diseases still represents a major health problem in childhood. Despite many different options are currently available for the diagnostic work‐up and management, the overall disease control in terms of impact on quality of life, morbidity and mortality, is not yet satisf...

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Bibliographic Details
Published in:Pediatric allergy and immunology 2015-12, Vol.26 (8), p.702-710
Main Authors: Caminati, Marco, Durić-Filipović, Ivana, Arasi, Stefania, Peroni, Diego G., Živković, Zorica, Senna, Gianenrico
Format: Article
Language:English
Subjects:
airway
allergy
Animals
biomarkers
Biomarkers - metabolism
Biomedical Research
Child
childhood
diagnostics
Early Diagnosis
environment
Gene-Environment Interaction
Humans
life quality
Mortality
prediction
Prognosis
Respiratory Hypersensitivity - diagnosis
Respiratory Hypersensitivity - therapy
Risk Factors
therapy
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Description
Summary:The burden of allergic airway diseases still represents a major health problem in childhood. Despite many different options are currently available for the diagnostic work‐up and management, the overall disease control in terms of impact on quality of life, morbidity and mortality, is not yet satisfactory. The extreme variability of individual risk factors and severity determinants may account for it. On the other side, the knowledge of the multifaceted allergy background could pave the way to primary prevention, early intervention and disease course modification. In fact, most of current research is focusing on the identification of biological and clinical predictive markers of allergy and asthma onset. This review aims at summarizing the latest achievements concerning the complex inter‐relation between genetic predisposition and environmental factors, and their impact on prevention strategies and early identification of at risk subjects. An update on the diagnostic and monitoring tools as well as an insight into the newest treatments options is also provided.
ISSN:0905-6157
1399-3038
DOI:10.1111/pai.12509