Semilobar Holoprosencephaly Associated with Multiple Malformations in a Foal

A full‐term male foal born in a farm holidays in Maremma (Tuscany, Italy) was euthanized shortly after birth due to the presence of several malformations. The rostral maxilla and the nasal septum were deviated to the right (wry nose), and a severe cervico‐thoracic scoliosis and anus atresia were evi...

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Bibliographic Details
Published in:Anatomia, histologia, embryologia histologia, embryologia, 2016-04, Vol.45 (2), p.148-153
Main Authors: Pintore, M. D., Cantile, C.
Format: Article
Language:English
Subjects:
Abnormalities, Multiple - pathology
Abnormalities, Multiple - veterinary
Animals
Animals, Newborn - abnormalities
Anus, Imperforate - pathology
Anus, Imperforate - veterinary
Brain - abnormalities
Brain - pathology
Ethmoid Bone - abnormalities
Holoprosencephaly - complications
Holoprosencephaly - pathology
Holoprosencephaly - veterinary
Horses - abnormalities
Ileum - abnormalities
Kidney - abnormalities
Male
Maxilla - abnormalities
Nasal Septum - abnormalities
Scoliosis - pathology
Scoliosis - veterinary
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Summary:A full‐term male foal born in a farm holidays in Maremma (Tuscany, Italy) was euthanized shortly after birth due to the presence of several malformations. The rostral maxilla and the nasal septum were deviated to the right (wry nose), and a severe cervico‐thoracic scoliosis and anus atresia were evident. Necropsy revealed ileum atresia and agenesis of the right kidney. The brain showed an incomplete separation of the hemispheres of the rostral third of the forebrain and the olfactory bulbs and tracts were absent (olfactory aplasia). A diagnosis of semilobar holoprosencephaly (HPE) was achieved. This is the first case of semilobar HPE associated with other organ anomalies in horses.
ISSN:0340-2096
1439-0264
DOI:10.1111/ahe.12175