Distinguishing between stochasticity and determinism: Examples from cell cycle duration variability

We describe a recent approach for distinguishing between stochastic and deterministic sources of variability, focusing on the mammalian cell cycle. Variability between cells is often attributed to stochastic noise, although it may be generated by deterministic components. Interestingly, lineage info...

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Bibliographic Details
Published in:BioEssays 2016, Vol.38 (1), p.8-13
Main Authors: Pearl Mizrahi, Sivan, Sandler, Oded, Lande‐Diner, Laura, Balaban, Nathalie Q, Simon, Itamar
Format: Article
Language:English
Subjects:
Cell cycle
Cell Cycle - genetics
Cell Division - genetics
Cell Lineage
circadian rhythm
Determinism
Humans
inheritance
lineage
mammals
Models, Theoretical
Neoplasms - genetics
single cell
Stochastic Processes
stochasticity
tissues
variability
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Summary:We describe a recent approach for distinguishing between stochastic and deterministic sources of variability, focusing on the mammalian cell cycle. Variability between cells is often attributed to stochastic noise, although it may be generated by deterministic components. Interestingly, lineage information can be used to distinguish between variability and determinism. Analysis of correlations within a lineage of the mammalian cell cycle duration revealed its deterministic nature. Here, we discuss the sources of such variability and the possibility that the underlying deterministic process is due to the circadian clock. Finally, we discuss the “kicked cell cycle” model and its implication on the study of the cell cycle in healthy and cancerous tissues.
ISSN:0265-9247
1521-1878
DOI:10.1002/bies.201500113