Perfluorocarbon-Loaded Hollow Bi2Se3 Nanoparticles for Timely Supply of Oxygen under Near-Infrared Light to Enhance the Radiotherapy of Cancer

Hollow Bi2Se3 nanoparticles prepared by a cation exchange method are loaded with perfluorocarbon as an oxygen carrier. With these nanoparticles, a promising concept is demonstrated to enhance radiotherapy by not only using their X‐ray‐absorbing ability to locally concentrate radiation energy in the...

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Bibliographic Details
Published in:Advanced materials (Weinheim) 2016-04, Vol.28 (14), p.2716-2723
Main Authors: Song, Guosheng, Liang, Chao, Yi, Xuan, Zhao, Qi, Cheng, Liang, Yang, Kai, Liu, Zhuang
Format: Article
Language:English
Subjects:
Animals
Bismuth - chemistry
cation exchange
Cell Line, Tumor
Cell Survival - drug effects
Cell Survival - radiation effects
DNA Damage - drug effects
DNA Damage - radiation effects
enhanced radiation therapy
Fluorocarbons - chemistry
hollow structures
Infrared Rays
Metal Nanoparticles - chemistry
Metal Nanoparticles - toxicity
Metal Nanoparticles - ultrastructure
Mice
Microscopy, Electron, Transmission
Neoplasms - drug therapy
Neoplasms - pathology
Neoplasms - radiotherapy
Organoselenium Compounds - chemistry
overcome tumor hypoxia
Oxygen - chemistry
Oxygen - metabolism
oxygen carries
Polyethylene Glycols - chemistry
Transplantation, Homologous
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Summary:Hollow Bi2Se3 nanoparticles prepared by a cation exchange method are loaded with perfluorocarbon as an oxygen carrier. With these nanoparticles, a promising concept is demonstrated to enhance radiotherapy by not only using their X‐ray‐absorbing ability to locally concentrate radiation energy in the tumor, but also employing near‐infrared light to trigger burst release of oxygen from the nanoparticles to overcome hypoxia‐associated radio‐resistance.
ISSN:0935-9648
1521-4095
DOI:10.1002/adma.201504617