Diaphragmatic fatigue during inspiratory muscle loading in normoxia and hypoxia

Highlights • We investigated the effect of hypoxia on the progression of diaphragmatic fatigue during inspiratory muscle loading. • In normoxia the progression of diaphragmatic fatigue during inspiratory muscle loading follows an exponential decay. • In hypoxia the progression of diaphragmatic fatig...

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Bibliographic Details
Published in:Respiratory physiology & neurobiology 2016-06, Vol.227, p.1-8
Main Authors: Walker, David Johannes, Farquharson, Franziska, Klenze, Hannes, Walterspacher, Stephan, Storz, Lucia, Duerschmied, Daniel, Roecker, Kai, Kabitz, Hans-Joachim
Format: Article
Language:English
Subjects:
Adult
Anthropometry
Diaphragm
Diaphragm - physiology
Diaphragm - physiopathology
Female
Humans
Hypoxia - physiopathology
Hypoxic effects
Inhalation - physiology
Inspiratory muscle loading
Linear Models
Lung Volume Measurements
Magnetic Fields
Male
Medical Education
Muscle Fatigue - physiology
Nonlinear Dynamics
Phrenic Nerve - physiology
Pressure
Pulmonary/Respiratory
Single-Blind Method
Threshold loading
Twitch transdiaphragmatic pressure
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Summary:Highlights • We investigated the effect of hypoxia on the progression of diaphragmatic fatigue during inspiratory muscle loading. • In normoxia the progression of diaphragmatic fatigue during inspiratory muscle loading follows an exponential decay. • In hypoxia the progression of diaphragmatic fatigue during inspiratory muscle loading follows a linear decline.
ISSN:1569-9048
1878-1519
DOI:10.1016/j.resp.2016.01.006