Effects of Hypobaric Hypoxia in Various Modes on Expression of Neurogenesis Marker NeuroD2 in the Dentate Gyrus of Rats Hippocampus

The expression of neurogenesis marker – NeuroD2 transcription factor – in the hippocampal dentate gyrus was studied in rats exposed to severe destructive hypoxia, a single or three episodes of moderate hypobaric hypoxia, preconditioned severe hypoxia, and severe hypoxia followed by 3 sessions of pos...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2016-02, Vol.160 (4), p.510-513
Main Authors: Vetrovoi, O. V., Rybnikova, E. A., Glushchenko, T. S., Samoilov, M. O.
Format: Article
Language:English
Subjects:
Adaptation, Physiological - physiology
Animals
Basic Helix-Loop-Helix Transcription Factors - metabolism
Biomedical and Life Sciences
Biomedicine
Brain
Cell Biology
Cell Hypoxia - physiology
Dentate Gyrus - metabolism
Internal Medicine
Ischemic Preconditioning
Laboratory Medicine
Male
Neurogenesis - physiology
Neuropeptides - metabolism
Neuroprotective Agents
Pathology
Rats
Rats, Wistar
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Summary:The expression of neurogenesis marker – NeuroD2 transcription factor – in the hippocampal dentate gyrus was studied in rats exposed to severe destructive hypoxia, a single or three episodes of moderate hypobaric hypoxia, preconditioned severe hypoxia, and severe hypoxia followed by 3 sessions of postconditioning by moderate hypobaric hypoxia. All the studied hypoxic exposure modes led to an increase of NeuroD2 level. Three-fold moderate hypoxia per se and in the preconditioning mode (followed by exposure to severe hypoxia) produced most pronounced up-regulatory effect on NeuroD2 expression. The results indicated that stimulation of neurogenesis processes seemed to be one of the aspects of the neuroprotective effect of three-fold preconditioning moderate hypoxia, but not of hypoxic postconditioning.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-016-3209-5