Effects of Hypobaric Hypoxia in Various Modes on Expression of Neurogenesis Marker NeuroD2 in the Dentate Gyrus of Rats Hippocampus

The expression of neurogenesis marker – NeuroD2 transcription factor – in the hippocampal dentate gyrus was studied in rats exposed to severe destructive hypoxia, a single or three episodes of moderate hypobaric hypoxia, preconditioned severe hypoxia, and severe hypoxia followed by 3 sessions of pos...

Full description

Saved in:
Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2016-02, Vol.160 (4), p.510-513
Main Authors: Vetrovoi, O. V., Rybnikova, E. A., Glushchenko, T. S., Samoilov, M. O.
Format: Article
Language:English
Subjects:
Adaptation, Physiological - physiology
Animals
Basic Helix-Loop-Helix Transcription Factors - metabolism
Biomedical and Life Sciences
Biomedicine
Brain
Cell Biology
Cell Hypoxia - physiology
Dentate Gyrus - metabolism
Internal Medicine
Ischemic Preconditioning
Laboratory Medicine
Male
Neurogenesis - physiology
Neuropeptides - metabolism
Neuroprotective Agents
Pathology
Rats
Rats, Wistar
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c503t-42bc0944209843cb576907ed55542c5666b841008dbdcbc774b02f5cda11ce663
cites cdi_FETCH-LOGICAL-c503t-42bc0944209843cb576907ed55542c5666b841008dbdcbc774b02f5cda11ce663
container_end_page 513
container_issue 4
container_start_page 510
container_title Bulletin of experimental biology and medicine
container_volume 160
creator Vetrovoi, O. V.
Rybnikova, E. A.
Glushchenko, T. S.
Samoilov, M. O.
description The expression of neurogenesis marker – NeuroD2 transcription factor – in the hippocampal dentate gyrus was studied in rats exposed to severe destructive hypoxia, a single or three episodes of moderate hypobaric hypoxia, preconditioned severe hypoxia, and severe hypoxia followed by 3 sessions of postconditioning by moderate hypobaric hypoxia. All the studied hypoxic exposure modes led to an increase of NeuroD2 level. Three-fold moderate hypoxia per se and in the preconditioning mode (followed by exposure to severe hypoxia) produced most pronounced up-regulatory effect on NeuroD2 expression. The results indicated that stimulation of neurogenesis processes seemed to be one of the aspects of the neuroprotective effect of three-fold preconditioning moderate hypoxia, but not of hypoxic postconditioning.
doi_str_mv 10.1007/s10517-016-3209-5
format article
fullrecord <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_1780513734</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A452494564</galeid><sourcerecordid>A452494564</sourcerecordid><originalsourceid>FETCH-LOGICAL-c503t-42bc0944209843cb576907ed55542c5666b841008dbdcbc774b02f5cda11ce663</originalsourceid><addsrcrecordid>eNqNkl9r1TAYxoMo7mz6AbyRgiC76UzS_Ovl2I47wlQQ9Tak6dtzMtumJi3sXPvFTdcpZ6IguUjy5ve84UkehF4QfEYwlm8iwZzIHBORFxSXOX-EVoTLIleUksdohROUM6XUETqO8WbeYkGeoiMqVFkqplbox7ppwI4x80222Q--MsHZu9WtM5nrs6-p4KeYvfc1JKrP1rdDgBhdWibNB5iC30IP0SXGhG8QltolndXjDrJL6EczQna1D9PdPZ9Mum_jhsFb0w1TfIaeNKaN8Px-PkFf3q4_X2zy649X7y7Or3PLcTHmjFYWl4wlp4oVtuJSlFhCzTln1HIhRKVYehdVV7WtrJSswrThtjaEWBCiOEGnS98h-O8TxFF3LlpoW9NDsqiJVOk9C1mw_0AlVglXM_rqD_TGT6FPRmaKEKxKeUBtTQva9Y0fg7FzU33OOGUl42Kmzv5CpVFD56zvoXGp_kDw-kCwA9OOu-jbaUzfEx-CZAFt8DEGaPQQXGfCXhOs5zDpJUw6hUnPYdI8aV7eO5uqDurfil_pSQBdgJiO-i2EA-v_7PoTzk3Q-w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1771108974</pqid></control><display><type>article</type><title>Effects of Hypobaric Hypoxia in Various Modes on Expression of Neurogenesis Marker NeuroD2 in the Dentate Gyrus of Rats Hippocampus</title><source>Springer Link</source><creator>Vetrovoi, O. V. ; Rybnikova, E. A. ; Glushchenko, T. S. ; Samoilov, M. O.</creator><creatorcontrib>Vetrovoi, O. V. ; Rybnikova, E. A. ; Glushchenko, T. S. ; Samoilov, M. O.</creatorcontrib><description>The expression of neurogenesis marker – NeuroD2 transcription factor – in the hippocampal dentate gyrus was studied in rats exposed to severe destructive hypoxia, a single or three episodes of moderate hypobaric hypoxia, preconditioned severe hypoxia, and severe hypoxia followed by 3 sessions of postconditioning by moderate hypobaric hypoxia. All the studied hypoxic exposure modes led to an increase of NeuroD2 level. Three-fold moderate hypoxia per se and in the preconditioning mode (followed by exposure to severe hypoxia) produced most pronounced up-regulatory effect on NeuroD2 expression. The results indicated that stimulation of neurogenesis processes seemed to be one of the aspects of the neuroprotective effect of three-fold preconditioning moderate hypoxia, but not of hypoxic postconditioning.</description><identifier>ISSN: 0007-4888</identifier><identifier>EISSN: 1573-8221</identifier><identifier>DOI: 10.1007/s10517-016-3209-5</identifier><identifier>PMID: 26899848</identifier><identifier>CODEN: BEXBAN</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Adaptation, Physiological - physiology ; Animals ; Basic Helix-Loop-Helix Transcription Factors - metabolism ; Biomedical and Life Sciences ; Biomedicine ; Brain ; Cell Biology ; Cell Hypoxia - physiology ; Dentate Gyrus - metabolism ; Internal Medicine ; Ischemic Preconditioning ; Laboratory Medicine ; Male ; Neurogenesis - physiology ; Neuropeptides - metabolism ; Neuroprotective Agents ; Pathology ; Rats ; Rats, Wistar</subject><ispartof>Bulletin of experimental biology and medicine, 2016-02, Vol.160 (4), p.510-513</ispartof><rights>Springer Science+Business Media New York 2016</rights><rights>COPYRIGHT 2016 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c503t-42bc0944209843cb576907ed55542c5666b841008dbdcbc774b02f5cda11ce663</citedby><cites>FETCH-LOGICAL-c503t-42bc0944209843cb576907ed55542c5666b841008dbdcbc774b02f5cda11ce663</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26899848$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vetrovoi, O. V.</creatorcontrib><creatorcontrib>Rybnikova, E. A.</creatorcontrib><creatorcontrib>Glushchenko, T. S.</creatorcontrib><creatorcontrib>Samoilov, M. O.</creatorcontrib><title>Effects of Hypobaric Hypoxia in Various Modes on Expression of Neurogenesis Marker NeuroD2 in the Dentate Gyrus of Rats Hippocampus</title><title>Bulletin of experimental biology and medicine</title><addtitle>Bull Exp Biol Med</addtitle><addtitle>Bull Exp Biol Med</addtitle><description>The expression of neurogenesis marker – NeuroD2 transcription factor – in the hippocampal dentate gyrus was studied in rats exposed to severe destructive hypoxia, a single or three episodes of moderate hypobaric hypoxia, preconditioned severe hypoxia, and severe hypoxia followed by 3 sessions of postconditioning by moderate hypobaric hypoxia. All the studied hypoxic exposure modes led to an increase of NeuroD2 level. Three-fold moderate hypoxia per se and in the preconditioning mode (followed by exposure to severe hypoxia) produced most pronounced up-regulatory effect on NeuroD2 expression. The results indicated that stimulation of neurogenesis processes seemed to be one of the aspects of the neuroprotective effect of three-fold preconditioning moderate hypoxia, but not of hypoxic postconditioning.</description><subject>Adaptation, Physiological - physiology</subject><subject>Animals</subject><subject>Basic Helix-Loop-Helix Transcription Factors - metabolism</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Brain</subject><subject>Cell Biology</subject><subject>Cell Hypoxia - physiology</subject><subject>Dentate Gyrus - metabolism</subject><subject>Internal Medicine</subject><subject>Ischemic Preconditioning</subject><subject>Laboratory Medicine</subject><subject>Male</subject><subject>Neurogenesis - physiology</subject><subject>Neuropeptides - metabolism</subject><subject>Neuroprotective Agents</subject><subject>Pathology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><issn>0007-4888</issn><issn>1573-8221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNqNkl9r1TAYxoMo7mz6AbyRgiC76UzS_Ovl2I47wlQQ9Tak6dtzMtumJi3sXPvFTdcpZ6IguUjy5ve84UkehF4QfEYwlm8iwZzIHBORFxSXOX-EVoTLIleUksdohROUM6XUETqO8WbeYkGeoiMqVFkqplbox7ppwI4x80222Q--MsHZu9WtM5nrs6-p4KeYvfc1JKrP1rdDgBhdWibNB5iC30IP0SXGhG8QltolndXjDrJL6EczQna1D9PdPZ9Mum_jhsFb0w1TfIaeNKaN8Px-PkFf3q4_X2zy649X7y7Or3PLcTHmjFYWl4wlp4oVtuJSlFhCzTln1HIhRKVYehdVV7WtrJSswrThtjaEWBCiOEGnS98h-O8TxFF3LlpoW9NDsqiJVOk9C1mw_0AlVglXM_rqD_TGT6FPRmaKEKxKeUBtTQva9Y0fg7FzU33OOGUl42Kmzv5CpVFD56zvoXGp_kDw-kCwA9OOu-jbaUzfEx-CZAFt8DEGaPQQXGfCXhOs5zDpJUw6hUnPYdI8aV7eO5uqDurfil_pSQBdgJiO-i2EA-v_7PoTzk3Q-w</recordid><startdate>20160201</startdate><enddate>20160201</enddate><creator>Vetrovoi, O. V.</creator><creator>Rybnikova, E. A.</creator><creator>Glushchenko, T. S.</creator><creator>Samoilov, M. O.</creator><general>Springer US</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>20160201</creationdate><title>Effects of Hypobaric Hypoxia in Various Modes on Expression of Neurogenesis Marker NeuroD2 in the Dentate Gyrus of Rats Hippocampus</title><author>Vetrovoi, O. V. ; Rybnikova, E. A. ; Glushchenko, T. S. ; Samoilov, M. O.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c503t-42bc0944209843cb576907ed55542c5666b841008dbdcbc774b02f5cda11ce663</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adaptation, Physiological - physiology</topic><topic>Animals</topic><topic>Basic Helix-Loop-Helix Transcription Factors - metabolism</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Brain</topic><topic>Cell Biology</topic><topic>Cell Hypoxia - physiology</topic><topic>Dentate Gyrus - metabolism</topic><topic>Internal Medicine</topic><topic>Ischemic Preconditioning</topic><topic>Laboratory Medicine</topic><topic>Male</topic><topic>Neurogenesis - physiology</topic><topic>Neuropeptides - metabolism</topic><topic>Neuroprotective Agents</topic><topic>Pathology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vetrovoi, O. V.</creatorcontrib><creatorcontrib>Rybnikova, E. A.</creatorcontrib><creatorcontrib>Glushchenko, T. S.</creatorcontrib><creatorcontrib>Samoilov, M. O.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Databases</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Bulletin of experimental biology and medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vetrovoi, O. V.</au><au>Rybnikova, E. A.</au><au>Glushchenko, T. S.</au><au>Samoilov, M. O.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Hypobaric Hypoxia in Various Modes on Expression of Neurogenesis Marker NeuroD2 in the Dentate Gyrus of Rats Hippocampus</atitle><jtitle>Bulletin of experimental biology and medicine</jtitle><stitle>Bull Exp Biol Med</stitle><addtitle>Bull Exp Biol Med</addtitle><date>2016-02-01</date><risdate>2016</risdate><volume>160</volume><issue>4</issue><spage>510</spage><epage>513</epage><pages>510-513</pages><issn>0007-4888</issn><eissn>1573-8221</eissn><coden>BEXBAN</coden><abstract>The expression of neurogenesis marker – NeuroD2 transcription factor – in the hippocampal dentate gyrus was studied in rats exposed to severe destructive hypoxia, a single or three episodes of moderate hypobaric hypoxia, preconditioned severe hypoxia, and severe hypoxia followed by 3 sessions of postconditioning by moderate hypobaric hypoxia. All the studied hypoxic exposure modes led to an increase of NeuroD2 level. Three-fold moderate hypoxia per se and in the preconditioning mode (followed by exposure to severe hypoxia) produced most pronounced up-regulatory effect on NeuroD2 expression. The results indicated that stimulation of neurogenesis processes seemed to be one of the aspects of the neuroprotective effect of three-fold preconditioning moderate hypoxia, but not of hypoxic postconditioning.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>26899848</pmid><doi>10.1007/s10517-016-3209-5</doi><tpages>4</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0007-4888
ispartof Bulletin of experimental biology and medicine, 2016-02, Vol.160 (4), p.510-513
issn 0007-4888
1573-8221
language eng
recordid cdi_proquest_miscellaneous_1780513734
source Springer Link
subjects Adaptation, Physiological - physiology
Animals
Basic Helix-Loop-Helix Transcription Factors - metabolism
Biomedical and Life Sciences
Biomedicine
Brain
Cell Biology
Cell Hypoxia - physiology
Dentate Gyrus - metabolism
Internal Medicine
Ischemic Preconditioning
Laboratory Medicine
Male
Neurogenesis - physiology
Neuropeptides - metabolism
Neuroprotective Agents
Pathology
Rats
Rats, Wistar
title Effects of Hypobaric Hypoxia in Various Modes on Expression of Neurogenesis Marker NeuroD2 in the Dentate Gyrus of Rats Hippocampus
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-04T21%3A57%3A33IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effects%20of%20Hypobaric%20Hypoxia%20in%20Various%20Modes%20on%20Expression%20of%20Neurogenesis%20Marker%20NeuroD2%20in%20the%20Dentate%20Gyrus%20of%20Rats%20Hippocampus&rft.jtitle=Bulletin%20of%20experimental%20biology%20and%20medicine&rft.au=Vetrovoi,%20O.%20V.&rft.date=2016-02-01&rft.volume=160&rft.issue=4&rft.spage=510&rft.epage=513&rft.pages=510-513&rft.issn=0007-4888&rft.eissn=1573-8221&rft.coden=BEXBAN&rft_id=info:doi/10.1007/s10517-016-3209-5&rft_dat=%3Cgale_proqu%3EA452494564%3C/gale_proqu%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c503t-42bc0944209843cb576907ed55542c5666b841008dbdcbc774b02f5cda11ce663%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1771108974&rft_id=info:pmid/26899848&rft_galeid=A452494564&rfr_iscdi=true