Inhibiting neuroinflammation: The role and therapeutic potential of GABA in neuro-immune interactions

Highlights • Inflammatory stimuli decrease GABAergic neuron density and GAD65/67. • Inflammatory mediators modulate conductance and expression of GABAA receptors. • GABAB receptor expression is upregulated by inflammatory stimuli. • GABAA receptor agonists and positive allosteric exert anti-inflamma...

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Bibliographic Details
Published in:Brain, behavior, and immunity behavior, and immunity, 2016-05, Vol.54, p.260-277
Main Authors: Crowley, Tadhg, Cryan, John F, Downer, Eric J, O’Leary, Olivia F
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
Anti-Inflammatory Agents - therapeutic use
Baclofen
GABA
GABA Agonists - metabolism
GABA Antagonists - metabolism
GABAA receptor
GABAB receptor
gamma-Aminobutyric Acid - immunology
gamma-Aminobutyric Acid - metabolism
gamma-Aminobutyric Acid - pharmacology
Glia
Humans
Inflammation
Inflammation - drug therapy
Inflammation - immunology
Inflammation - metabolism
Inflammation - pathology
Neuroimmunomodulation - immunology
Neuroinflammation
Psychiatry
Receptors, GABA - immunology
Receptors, GABA - metabolism
Toll-like receptor
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Summary:Highlights • Inflammatory stimuli decrease GABAergic neuron density and GAD65/67. • Inflammatory mediators modulate conductance and expression of GABAA receptors. • GABAB receptor expression is upregulated by inflammatory stimuli. • GABAA receptor agonists and positive allosteric exert anti-inflammatory effects. • The GABAB receptor agonist, baclofen, has anti-inflammatory effects.
ISSN:0889-1591
1090-2139
DOI:10.1016/j.bbi.2016.02.001