Effect of Biologically Active Substances Derived from Hydrobionts of the Pacific Ocean on Parameters of Lipid Metabolism during Experimental Hypercholesterolemia

We studied the effect of biologically active substances derived from hydrobionts, namely maristim (natural product from sea urchin roe) and fucolam (polysaccharides of fucoidan and calcium alginate from brown algae) on blood biochemistry in the mouse model of nutritional hypercholesterolemia. Marist...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2014-12, Vol.158 (2), p.188-191
Main Authors: Kuznetsova, T. A., Kryzhanovskii, S. P., Bogdanovich, L. N., Besednova, N. N.
Format: Article
Language:English
Subjects:
Alginates - pharmacology
Animals
Biological Products - pharmacology
Biomedical and Life Sciences
Biomedicine
Blood Chemical Analysis
Carbohydrate Metabolism - drug effects
Carbohydrate Metabolism - physiology
Cell Biology
Complex Mixtures - pharmacology
Diet, Atherogenic
Echinoidea
Enzymes
Glucuronic Acid - pharmacology
Hexuronic Acids - pharmacology
Hypercholesterolemia
Hypercholesterolemia - etiology
Hypercholesterolemia - metabolism
Internal Medicine
Laboratory Medicine
Lipid Metabolism - drug effects
Lipid Metabolism - physiology
Mice
Oceans
Pacific Ocean
Pathology
Phaeophyceae - chemistry
Physiological aspects
Polysaccharides
Polysaccharides - pharmacology
Sea Urchins - chemistry
Transaminases - metabolism
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Summary:We studied the effect of biologically active substances derived from hydrobionts, namely maristim (natural product from sea urchin roe) and fucolam (polysaccharides of fucoidan and calcium alginate from brown algae) on blood biochemistry in the mouse model of nutritional hypercholesterolemia. Maristim and fucolam are found to be capable to normalize the levels of the major indicators of lipid and carbohydrate metabolism and aminotransferase enzyme activity in terms of atherogenic load. Correction action of biologically active substances is more expressed in combined application. Identified experimentally normalizing effects of maristim and on lipid and carbohydrate metabolism allow us to recommend the further study in clinical trials of these biologically active substances and based on them additives.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-014-2719-2