Altered brain network centrality in depressed Parkinson's disease patients

ABSTRACT Background Depression is a relatively common and serious nonmotor symptom of Parkinson's disease (PD), which reduces the quality of patients' life. Although disturbances in some related brain networks have been reported, the pathophysiology of depression in PD is still unclear. He...

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Published in:Movement disorders 2015-11, Vol.30 (13), p.1777-1784
Main Authors: Lou, Yuting, Huang, Peiyu, Li, Dan, Cen, Zhidong, Wang, Bo, Gao, Jixiang, Xuan, Min, Yu, Hualiang, Zhang, Minming, Luo, Wei
Format: Article
Language:English
Subjects:
Aged
Analysis of Variance
Brain - blood supply
Brain - physiopathology
Case-Control Studies
depression
Depressive Disorder, Major - etiology
Depressive Disorder, Major - pathology
Female
functional connectivity
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Male
Middle Aged
Movement disorders
Neural Pathways - physiology
Neurologic Examination
Oxygen - blood
Parkinson Disease - complications
Parkinson's disease
Psychiatric Status Rating Scales
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Summary:ABSTRACT Background Depression is a relatively common and serious nonmotor symptom of Parkinson's disease (PD), which reduces the quality of patients' life. Although disturbances in some related brain networks have been reported, the pathophysiology of depression in PD is still unclear. Here, we aim to investigate whole‐brain functional connectivity patterns in depressed PD patients. Methods We recruited 17 PD patients diagnosed with major depressive disorder, 17 PD patients without depression, and 17 healthy control subjects. Resting‐state functional MRI and eigenvector centrality mapping were used to identify functional connectivity alterations among these groups. Results Results showed that depressed PD patients had decreased functional connectivity in the left dorsolateral prefrontal cortex and right superior temporal gyrus and increased functional connectivity in the right posterior cingulate cortex, compared to nondepressed patients. In addition, there was a significant negative correlation between functional connectivity and depression scores in the posterior cingulate cortex. Conclusions This study suggests that functional connectivity changes in certain nodes of brain networks might contribute to depression in patients with PD. © 2015 International Parkinson and Movement Disorder Society
ISSN:0885-3185
1531-8257
DOI:10.1002/mds.26321