Regulation of neuronal migration, an emerging topic in autism spectrum disorders

Autism spectrum disorders (ASD) encompass a group of neurodevelopmental diseases that demonstrate strong heritability, however, the inheritance is not simple and many genes have been associated with these disorders. ASD is regarded as a neurodevelopmental disorder, and abnormalities at different dev...

Full description

Saved in:
Bibliographic Details
Published in:Journal of neurochemistry 2016-02, Vol.136 (3), p.440-456
Main Authors: Reiner, Orly, Karzbrun, Eyal, Kshirsagar, Aditya, Kaibuchi, Kozo
Format: Article
Language:English
Subjects:
Astrotactin 2 ASTN2
Autism
Autism Spectrum Disorder - genetics
Autism Spectrum Disorder - pathology
Autism susceptibility candidate 2 AUTS2
Brain - pathology
Cell adhesion & migration
Cell Movement - physiology
Contactin‐associated protein‐like 2 CNTNAP2
Distal‐less homeobox 1/2 DLX1/2
Humans
Neurochemistry
Neurogenesis - genetics
Neuronal migration
Neurons - physiology
NudE nuclear distribution E homolog 1 NDE1
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Autism spectrum disorders (ASD) encompass a group of neurodevelopmental diseases that demonstrate strong heritability, however, the inheritance is not simple and many genes have been associated with these disorders. ASD is regarded as a neurodevelopmental disorder, and abnormalities at different developmental stages are part of the disease etiology. This review provides a general background on neuronal migration during brain development and discusses recent advancements in the field connecting ASD and aberrant neuronal migration. We propose that neuronal migration impairment may be an important common pathophysiology in autism spectrum disorders (ASD). This review provides a general background on neuronal migration during brain development and discusses recent advancements in the field connecting ASD and aberrant neuronal migration. We propose that neuronal migration impairment may be an important common pathophysiology in autism spectrum disorders (ASD). This review provides a general background on neuronal migration during brain development and discusses recent advancements in the field connecting ASD and aberrant neuronal migration.
ISSN:0022-3042
1471-4159
DOI:10.1111/jnc.13403