Psychotropic Activity of New Fluorinated Derivatives of Tetrahydrocarbasoles

Psychotropic properties of CA-7043× and CA-7050×, new fluorinated derivatives of tetrahydrocarbasoles, were examined on outbred CD1 mice and transgenic 5×FAD mice with Alzheimer disease. Both agents exerted cognitive-stimulating and anxiolytic effects in a dose of 5 mg/kg. In the new cage test, they...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2016-02, Vol.160 (4), p.455-458
Main Authors: Nikolaeva, N. S., Sokolov, V. B., Aksinenko, A. Yu, Ovchinnikov, R. K., Bachurin, S. O., Kinzirskii, A. S.
Format: Article
Language:English
Subjects:
Alzheimer Disease - drug therapy
Alzheimer's disease
Animals
Anti-Anxiety Agents - pharmacology
Anxiety - drug therapy
Behavior, Animal - drug effects
Biomedical and Life Sciences
Biomedicine
Carbazoles - pharmacology
Cell Biology
Disease Models, Animal
Exploratory Behavior - drug effects
Genetic engineering
Hydrocarbons, Fluorinated - pharmacology
Internal Medicine
Laboratory Medicine
Male
Maze Learning - drug effects
Mice
Mice, Transgenic
Pathology
Psychotropic Drugs - pharmacology
Tranquilizing drugs
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Summary:Psychotropic properties of CA-7043× and CA-7050×, new fluorinated derivatives of tetrahydrocarbasoles, were examined on outbred CD1 mice and transgenic 5×FAD mice with Alzheimer disease. Both agents exerted cognitive-stimulating and anxiolytic effects in a dose of 5 mg/kg. In the new cage test, they retarded extinction of orientation and exploratory behavior. CA-7043× produced an anxiolytic effect on CD1 mice assessed in the open-field test and exerted cognitive-stimulating action in the new location test. In the same tests, CA-7050× demonstrated the cognitive-stimulating and anxiolytic effects on transgenic 5×FAD mice.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-016-3195-7