Antagonists of Metabotropic Glutamate Receptors Prevent the Development of Audiogenic Seizures

Pretreatment with mGluR1 antagonist AIDA (1 mg/kg) nearly completely prevented the onset of tonic-clonic seizures and increased generation of NO in the cerebral cortex of rats with genetically determined audiogenic reaction to acoustic stimulation. Administration of mGluR5 antagonist MPEP (10 mg/kg)...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2015-05, Vol.159 (1), p.1-3
Main Authors: Bashkatova, V. G., Sudakov, S. K., Prast, H.
Format: Article
Language:English
Subjects:
Acoustic Stimulation - adverse effects
Animals
Biomedical and Life Sciences
Biomedicine
Cell Biology
Cerebral Cortex - drug effects
Cerebral Cortex - metabolism
Electron Spin Resonance Spectroscopy
Epilepsy, Reflex - etiology
Epilepsy, Reflex - physiopathology
Epilepsy, Reflex - prevention & control
Epilepsy, Tonic-Clonic - etiology
Epilepsy, Tonic-Clonic - physiopathology
Epilepsy, Tonic-Clonic - prevention & control
Excitatory Amino Acid Antagonists - pharmacology
Excitatory Amino Acid Antagonists - therapeutic use
Glutamate
Indans - pharmacology
Indans - therapeutic use
Internal Medicine
Laboratory Medicine
Male
Nerve Tissue Proteins - antagonists & inhibitors
Nerve Tissue Proteins - physiology
Nitric Oxide - biosynthesis
Nitric Oxide - physiology
Pathology
Physiology
Prevention
Pyridines - pharmacology
Pyridines - therapeutic use
Rats
Rats, Mutant Strains
Receptor, Metabotropic Glutamate 5 - antagonists & inhibitors
Receptor, Metabotropic Glutamate 5 - physiology
Receptors, Metabotropic Glutamate - antagonists & inhibitors
Receptors, Metabotropic Glutamate - physiology
Seizures (Medicine)
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Summary:Pretreatment with mGluR1 antagonist AIDA (1 mg/kg) nearly completely prevented the onset of tonic-clonic seizures and increased generation of NO in the cerebral cortex of rats with genetically determined audiogenic reaction to acoustic stimulation. Administration of mGluR5 antagonist MPEP (10 mg/kg) before audiogenic exposure was followed by a significant decrease in the degree of seizure and partially prevented increased generation of NO due to acoustic stimulation. These data indicate that mGlu receptors and NO play an important role in the pathogenetic mechanisms of audiogenic seizures.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-015-2874-0