Immunohistochemical Analysis and Electron Microscopy of Glial Cells in the Pancreas of Fetuses and Children

Schwann cells forming peri-insular glial sheath of the pancreatic islets in some mammals can be involved in the pathogenesis of diabetes mellitus. Human pancreatic cells contain small elongated or oval cells of unknown origin with S100-immunopositive processes. We found that cells with processes loc...

Full description

Saved in:
Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2015-09, Vol.159 (5), p.666-669
Main Authors: Krivova, Yu. S., Proshchina, A. E., Chernikov, V. P., Barabanov, V. M., Savel’ev, S. V.
Format: Article
Language:English
Subjects:
Autopsy
B cells
Biomedical and Life Sciences
Biomedicine
Cell Biology
Child, Preschool
Diabetes
Electron microscopy
Fetus
Gene Expression
Gestational Age
Humans
Immunohistochemistry
Infant
Infant, Newborn
Internal Medicine
Islets of Langerhans - metabolism
Islets of Langerhans - ultrastructure
Laboratory Medicine
Microscopy, Electron
Pancreatic Ducts - metabolism
Pancreatic Ducts - ultrastructure
Pathology
S100 Proteins - genetics
Schwann Cells - metabolism
Schwann Cells - ultrastructure
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Schwann cells forming peri-insular glial sheath of the pancreatic islets in some mammals can be involved in the pathogenesis of diabetes mellitus. Human pancreatic cells contain small elongated or oval cells of unknown origin with S100-immunopositive processes. We found that cells with processes located in pancreatic islets of human fetuses and children are similar to Schwann cells by their morphological and ultrastructural characteristics, immunopositive reaction for S100, and integration with nerve endings. In the pancreas of fetuses and children, Schwann cells are often seen in forming pancreatic islets and around the pancreatic ducts. The data suggests that Schwann cells can participate in the morphogenesis of human pancreatic islets.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-015-3043-1