Hepatocyte Apoptosis in Rats Exposed to Benzo(a)pyrene

We studied the effect of benzo(a)pyrene on activity of nuclear endonucleases and expression of molecular regulator of apoptosis Bcl-2 in liver cells in rats. Intraperitoneal injection of benzo(a)pyrene (in a total dose of 60 mg/kg body weight) reduced activity of nuclear endonucleases in the liver c...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2014-11, Vol.158 (1), p.150-152
Main Authors: Michurina, S. V., Arkhipov, S. A., Kolesnikov, S. I.
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Benzo(a)pyrene - toxicity
Biomedical and Life Sciences
Biomedicine
Carcinogens - toxicity
Cell Biology
Cell Nucleus - enzymology
Endonucleases - metabolism
Hepatocytes - drug effects
Hepatocytes - physiology
Internal Medicine
Laboratory Medicine
Liver - drug effects
Liver - pathology
Male
Pathology
Rats, Wistar
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Summary:We studied the effect of benzo(a)pyrene on activity of nuclear endonucleases and expression of molecular regulator of apoptosis Bcl-2 in liver cells in rats. Intraperitoneal injection of benzo(a)pyrene (in a total dose of 60 mg/kg body weight) reduced activity of nuclear endonucleases in the liver cells, which attests to inhibition of apoptosis by the nuclear pathway. Injection of the toxicant enhanced the expression of intracellular molecular regulator of apoptosis Bcl-2 protein in the liver cells, which attested to triggering of proapoptotic signaling in these cells and organism’s attempts to limit the development of apoptosis by the mitochondrial mechanism via activation of Bcl-2-dependent anti-apoptotic defense.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-014-2711-x