Role of JNK and Contribution of p53 into Growth Potential of Mesenchymal Progenitor Cells In Vitro

Specifi c JNK and p53 inhibitors stimulated the formation of fi broblast colonies (CFU-F) and clusters (ClFU-F) and increased proliferative activity of mesenchymal progenitor cells. No effects of inhibitors of JNK and p53 on differentiation of progenitor elements were revealed.

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2015-06, Vol.159 (2), p.245-247
Main Authors: Zyuz’kov, G. N., Zhdanov, V. V., Udut, E. V., Miroshnichenko, L. A., Danilets, M. G., Simanina, E. V., Trofimova, E. S., Chaikovskii, A. V., Agafonov, V. I., Sherstoboev, E. Yu, Minakova, M. Yu, Burmina, Ya. V., Udut, V. V., Dygai, A. M.
Format: Article
Language:English
Subjects:
Animals
Benzothiazoles - pharmacology
Biomedical and Life Sciences
Biomedicine
Cell Biology
Cell Proliferation - drug effects
Cell Proliferation - physiology
Hydroxyurea
In Vitro Techniques
Internal Medicine
Laboratory Medicine
Male
MAP Kinase Kinase 4 - antagonists & inhibitors
Mesenchymal Stromal Cells - metabolism
Mesenchymal Stromal Cells - physiology
Mice
Mice, Inbred CBA
Pathology
Protein Kinase Inhibitors - pharmacology
Signal Transduction - physiology
Statistics, Nonparametric
Stem cells
Toluene - analogs & derivatives
Toluene - pharmacology
Tumor proteins
Tumor Suppressor Protein p53 - antagonists & inhibitors
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Description
Summary:Specifi c JNK and p53 inhibitors stimulated the formation of fi broblast colonies (CFU-F) and clusters (ClFU-F) and increased proliferative activity of mesenchymal progenitor cells. No effects of inhibitors of JNK and p53 on differentiation of progenitor elements were revealed.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-015-2933-6