The Use of Autologous Mesenchymal Stem Cells for Cell Therapy of Patients with Amyotrophic Lateral Sclerosis in Belarus

We studied a new method of treatment of amyotrophic lateral sclerosis with autologous mesenchymal stem cells. Autologous mesenchymal stem cells were injected intravenously (intact cells) or via lumbar puncture (cells committed to neuronal differentiation). Evaluation of the results of cell therapy a...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2015-08, Vol.159 (4), p.576-581
Main Authors: Rushkevich, Yu. N., Kosmacheva, S. M., Zabrodets, G. V., Ignatenko, S. I., Goncharova, N. V., Severin, I. N., Likhachev, S. A., Potapnev, M. P.
Format: Article
Language:English
Subjects:
Adult
Aged
Amyotrophic lateral sclerosis
Amyotrophic Lateral Sclerosis - metabolism
Amyotrophic Lateral Sclerosis - pathology
Amyotrophic Lateral Sclerosis - therapy
Analysis
Biomedical and Life Sciences
Biomedicine
Care and treatment
Cell Biology
Cell Differentiation
Cells, Cultured
Development and progression
Female
Humans
Internal Medicine
Laboratory Medicine
Male
Mesenchymal Stem Cell Transplantation
Mesenchymal Stromal Cells - enzymology
Middle Aged
Nervous system diseases
Nestin - metabolism
Pathology
Phosphopyruvate Hydratase - metabolism
Proteins
Republic of Belarus
Stem cells
Transplantation
Transplantation, Autologous
Treatment Outcome
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Summary:We studied a new method of treatment of amyotrophic lateral sclerosis with autologous mesenchymal stem cells. Autologous mesenchymal stem cells were injected intravenously (intact cells) or via lumbar puncture (cells committed to neuronal differentiation). Evaluation of the results of cell therapy after 12-month follow-up revealed slowing down of the disease progression in 10 patients in comparison with the control group consisting of 15 patients. The cell therapy was safe for the patients.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-015-3017-3