Diffusion in the Corpus Callosum in Patients with Early Schizophrenia

Diffusion in the cerebral corpus callosum in patients with early schizophrenia was studied by diffusion tensor MRT and magnetic resonance spectroscopy. The fraction anisotropy coefficient in the corpus callosum knee was low as a result of high radial diffusion. Spectroscopy detected a decrease of N-...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2015-03, Vol.158 (5), p.611-613
Main Authors: Ublinskii, M. V., Semenova, N. A., Lukovkina, O. V., Sidorin, S. V., Lebedeva, I. S., Akhadov, T. A.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Anisotropy
Aspartic Acid - analogs & derivatives
Aspartic Acid - metabolism
Biomedical and Life Sciences
Biomedicine
Care and treatment
Cell Biology
Corpus Callosum - pathology
Diffusion Magnetic Resonance Imaging
Female
Humans
Internal Medicine
Laboratory Medicine
Male
Nuclear magnetic resonance spectroscopy
Pathology
Schizophrenia
Schizophrenia - pathology
Young Adult
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Summary:Diffusion in the cerebral corpus callosum in patients with early schizophrenia was studied by diffusion tensor MRT and magnetic resonance spectroscopy. The fraction anisotropy coefficient in the corpus callosum knee was low as a result of high radial diffusion. Spectroscopy detected a decrease of N-acetylaspartate level in the corpus callosum knee indicating axonal lesion during the early stage of schizophrenia.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-015-2818-8