Effects of a Preparation Containing Pantogam, Succinic Acid, and Chitosan on Activities of the Glutathione System and NADPH-Generating Enzymes in Rat Tissues under Conditions of Cerebral Ischemia/Reperfusion

Treatment with the complex preparation containing pantogam, succinic acid, and chitosan normalized the concentration of reduced glutathione and activities of glutathione peroxidase, glutathione reductase, and some NADPH-generating enzymes (glucose-6-phosphate dehydrogenase and NADPH-isocitrate dehyd...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2015-06, Vol.159 (2), p.221-224
Main Authors: Safonova, O. A., Popova, T. N., Slivkin, A. I., Talmi, Yu
Format: Article
Language:English
Subjects:
Amino acids
Animals
Antioxidants (Nutrients)
Biomedical and Life Sciences
Biomedicine
Brain Ischemia - complications
Cell Biology
Chitosan - administration & dosage
Chitosan - pharmacology
Drug Combinations
Enzymes
Free Radicals - metabolism
gamma-Aminobutyric Acid - administration & dosage
gamma-Aminobutyric Acid - analogs & derivatives
gamma-Aminobutyric Acid - pharmacology
Glucosephosphate Dehydrogenase - metabolism
Glutathione - metabolism
Glutathione Peroxidase - metabolism
Glutathione Reductase - metabolism
Internal Medicine
Isocitrate Dehydrogenase - metabolism
Laboratory Medicine
Male
NADP - metabolism
Oxidative Stress - physiology
Pantothenic Acid - administration & dosage
Pantothenic Acid - analogs & derivatives
Pantothenic Acid - pharmacology
Pathology
Phosphates
Physiological aspects
Rats
Reperfusion Injury - drug therapy
Reperfusion Injury - etiology
Succinates - administration & dosage
Succinates - pharmacology
Thiols
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Description
Summary:Treatment with the complex preparation containing pantogam, succinic acid, and chitosan normalized the concentration of reduced glutathione and activities of glutathione peroxidase, glutathione reductase, and some NADPH-generating enzymes (glucose-6-phosphate dehydrogenase and NADPH-isocitrate dehydrogenase) in animals with experimental hypoxia/reperfusion of the brain. These results can be explained by suppression of free radical oxidation and normalization of the antioxidant system related to the neuroprotective, antihypoxic, and antioxidant properties of these substances, their involvement into the regulation of cell metabolism under pathological conditions accompanied by oxidative stress.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-015-2927-4