Protection of Neurovascular Unit Cells with Lithium Chloride and Sodium Valproate Prevents Brain Damage in Neonatal Ischemia/Hypoxia

Here we studied the cytoprotective effect of lithium chloride and sodium valproate in the in vivo model of neonatal cerebral ischemia/hypoxia and analyzed the influence of these substances on the death of the major neurovascular unit components in experimental ischemia in vitro . Lithium chloride an...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2016, Vol.160 (3), p.313-318
Main Authors: Silachev, D. N., Plotnikov, E. Yu, Babenko, V. A., Savchenko, E. S., Zorova, L. D., Pevzner, I. B., Gulyaev, M. V., Pirogov, Yu. A., Sukhikh, G. T., Zorov, D. B.
Format: Article
Language:English
Subjects:
Animals
Animals, Newborn
Biomedical and Life Sciences
Biomedicine
Brain damage
Brain Injuries - drug therapy
Cell Biology
Dextrose
Glucose
Hypoxia - drug therapy
Hypoxia-Ischemia, Brain - drug therapy
Infants (Newborn)
Internal Medicine
Ischemia
Laboratory Medicine
Lithium Chloride - therapeutic use
Lithium compounds
Pathology
Rats
Valproic Acid - therapeutic use
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Summary:Here we studied the cytoprotective effect of lithium chloride and sodium valproate in the in vivo model of neonatal cerebral ischemia/hypoxia and analyzed the influence of these substances on the death of the major neurovascular unit components in experimental ischemia in vitro . Lithium chloride and sodium valproate effectively prevented death of neurons, astrocytes, and endothelial cells in the oxygen-glucose deprivation. This treatment protected the brain of newborn rats from ischemia/hypoxia injury. The results suggest that lithium and sodium valproate can be used for the treatment of neurodegenerative pathologies associated with hypoxia and ischemia in newborns.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-016-3159-y