Theoretical Analysis of a Self-Replicator With Reduced Template Inhibition Based on an Informational Leaving Group

The first non-enzymatic self-replicating systems, as proposed by von Kiedrowski (Angew Chem Int Ed Engl 25(10):932–935, 1986 ) and Orgel (Nature 327(6120):346–347, 1987 ), gave rise to the analytical background still used today to describe artificial replicators. What separates a self-replicating fr...

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Bibliographic Details
Published in:Journal of molecular evolution 2016-03, Vol.82 (2-3), p.93-109
Main Authors: Bigan, Erwan, Mattelaer, Henri-Philippe, Herdewijn, Piet
Format: Article
Language:English
Subjects:
Analysis
Animal Genetics and Genomics
Biomedical and Life Sciences
Cell Biology
DNA Replication - physiology
Enzymes
Evolutionary Biology
Life Sciences
Microbiology
Models, Genetic
Molecular biology
Nucleic Acids
Oligonucleotides
Origin of Life
Original Article
Plant Genetics and Genomics
Plant Sciences
Protein synthesis
Templates, Genetic
Theoretical analysis
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Summary:The first non-enzymatic self-replicating systems, as proposed by von Kiedrowski (Angew Chem Int Ed Engl 25(10):932–935, 1986 ) and Orgel (Nature 327(6120):346–347, 1987 ), gave rise to the analytical background still used today to describe artificial replicators. What separates a self-replicating from an autocatalytic system is the ability to pass on structural information (Orgel, Nature 358(6383):203–209, 1992 ). Utilising molecular information, nucleic acids were the first choice as prototypical examples. But early self-replicators showed parabolic over exponential growth due to the strongly bound template duplex after template-directed ligation of substrates. We propose a self-replicating scheme with a weakly bound template duplex, using an informational leaving group. Such a scheme is inspired by the role of tRNA as leaving group and information carrier during protein synthesis, and is based on our previous experience with nucleotide chemistry. We analyse theoretically this scheme and compare it to the classical minimal replicator model. We show that for an example hexanucleotide template mirroring that is used by von Kiedrowski (Bioorganic chemistry frontiers, 1993 ) for the analysis of the classical minimal replicator, the proposed scheme is expected to result in higher template self-replication rate. The proposed self-replicating scheme based on an informational leaving group is expected to outperform the classical minimal replicator because of a weaker template duplex bonding, resulting in reduced template inhibition.
ISSN:0022-2844
1432-1432
DOI:10.1007/s00239-016-9733-0