Oroxylin A Inhibits Allergic Airway Inflammation in Ovalbumin (OVA)-Induced Asthma Murine Model

Oroxylin A, a natural flavonoid isolated from the medicinal herb Scutellaria baicalensis Georgi , has been reported to have anti-inflammatory property. In this study, we aimed to investigate the protective effects and mechanism of oroxylin A on allergic inflammation in OVA-induced asthma murine mode...

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Bibliographic Details
Published in:Inflammation 2016-04, Vol.39 (2), p.867-872
Main Authors: Zhou, De-Gang, Diao, Bao-Zhong, Zhou, Wen, Feng, Jia-Long
Format: Article
Language:English
Subjects:
Animals
Anti-Inflammatory Agents - therapeutic use
Asthma - chemically induced
Asthma - drug therapy
Biomedical and Life Sciences
Biomedicine
Disease Models, Animal
Enzyme Activation - drug effects
Female
Flavonoids - therapeutic use
Immunoglobulin E - immunology
Immunology
Inflammation - drug therapy
Interleukin-13 - metabolism
Interleukin-4 - metabolism
Interleukin-5 - metabolism
Internal Medicine
Mice
Mice, Inbred BALB C
NF-kappa B - metabolism
Original Article
Ovalbumin
Pathology
Pharmacology/Toxicology
Plant Preparations - pharmacology
Rheumatology
Scutellaria baicalensis
Scutellaria baicalensis - metabolism
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Summary:Oroxylin A, a natural flavonoid isolated from the medicinal herb Scutellaria baicalensis Georgi , has been reported to have anti-inflammatory property. In this study, we aimed to investigate the protective effects and mechanism of oroxylin A on allergic inflammation in OVA-induced asthma murine model. BABL/c mice were sensitized and airway-challenged with OVA to induce asthma. Oroxylin A (15, 30, and 60 mg/kg) was administered by oral gavage 1 h before the OVA treatment on day 21 to 23. The results showed that oroxylin A attenuated OVA-induced lung histopathologic changes, airway hyperresponsiveness, and the number of inflammatory cells. Oroxylin A also inhibited the levels of IL-4, IL-5, IL-13, and OVA-specific IgE in BALF. Furthermore, oroxylin A significantly inhibited OVA-induced NF-κB activation. In conclusion, these results suggested that oroxylin A inhibited airway inflammation in OVA-induced asthma murine model by inhibiting NF-κB activation. These results suggested that oroxylin A was a potential therapeutic drug for treating allergic asthma.
ISSN:0360-3997
1573-2576
DOI:10.1007/s10753-016-0317-3