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The role of anterior midcingulate cortex in cognitive motor control

The rostral cingulate cortex has been associated with a multitude of cognitive control functions. Recent neuroimaging data suggest that the anterior midcingulate cortex (aMCC) has a key role for cognitive aspects of movement generation, i.e., intentional motor control. We here tested the functional...

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Published in:Human brain mapping 2014-06, Vol.35 (6), p.2741-2753
Main Authors: Hoffstaedter, Felix, Grefkes, Christian, Caspers, Svenja, Roski, Christian, Palomero-Gallagher, Nicola, Laird, Angie R., Fox, Peter T., Eickhoff, Simon B.
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container_end_page 2753
container_issue 6
container_start_page 2741
container_title Human brain mapping
container_volume 35
creator Hoffstaedter, Felix
Grefkes, Christian
Caspers, Svenja
Roski, Christian
Palomero-Gallagher, Nicola
Laird, Angie R.
Fox, Peter T.
Eickhoff, Simon B.
description The rostral cingulate cortex has been associated with a multitude of cognitive control functions. Recent neuroimaging data suggest that the anterior midcingulate cortex (aMCC) has a key role for cognitive aspects of movement generation, i.e., intentional motor control. We here tested the functional connectivity of this area using two complementary approaches: (1) resting‐state connectivity of the aMCC based on fMRI scans obtained in 100 subjects, and (2) functional connectivity in the context of explicit task conditions using meta‐analytic connectivity modeling (MACM) over 656 imaging experiment. Both approaches revealed a convergent functional network architecture of the aMCC with prefrontal, premotor and parietal cortices as well as anterior insula, area 44/45, cerebellum and dorsal striatum. To specifically test the role of the aMCC's task‐based functional connectivity in cognitive motor control, separate MACM analyses were conducted over “cognitive” and “action” related experimental paradigms. Both analyses confirmed the same task‐based connectivity pattern of the aMCC. While the “cognition” domain showed higher convergence of activity in supramodal association areas in prefrontal cortex and anterior insula, “action” related experiments yielded higher convergence in somatosensory and premotor areas. Secondly, to probe the functional specificity of the aMCC's convergent functional connectivity, it was compared with a neural network of intentional movement initiation. This exemplary comparison confirmed the involvement of the state independent FC network of the aMCC in the intentional generation of movements. In summary, the different experiments of the present study suggest that the aMCC constitute a key region in the network realizing intentional motor control. Hum Brain Mapp 35:2741–2753, 2014. © 2013 Wiley Periodicals, Inc.
doi_str_mv 10.1002/hbm.22363
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subjects anterior midcingulate cortex
cognitive motor control
fMRI
meta-analytic connectivity modeling
seed based resting-state analysis
title The role of anterior midcingulate cortex in cognitive motor control
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