Comparison of the Anti-inflammatory Effects of Proanthocyanidin, Quercetin, and Damnacanthal on Benzo(a)pyrene Exposed A549 Alveolar Cell Line

Phytochemical compounds are emerging as a new group of anti-inflammatory, antioxidant, and anti-cancer agents that help minimize toxicity in patients with pulmonary diseases. The goal of this study was to investigate the potential curative effects of Quercetin (QC), Damnacanthal (DAM), and Proanthoc...

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Bibliographic Details
Published in:Inflammation 2016-04, Vol.39 (2), p.744-751
Main Authors: Günay, Ersin, Celik, Sefa, Sarinc-Ulasli, Sevinc, Özyürek, Arzu, Hazman, Ömer, Günay, Sibel, Özdemir, Mehmet, Ünlü, Mehmet
Format: Article
Language:English
Subjects:
A549 Cells
Alveolar Epithelial Cells - immunology
Alveolar Epithelial Cells - pathology
Anthraquinones - pharmacology
Anti-Inflammatory Agents - pharmacology
Antioxidants - pharmacology
Apoptosis - drug effects
Benzo(a)pyrene
Biomedical and Life Sciences
Biomedicine
Cell Line, Tumor
Cell Survival - drug effects
Cytokines - biosynthesis
Glutathione - metabolism
Humans
Immunology
Inflammation - drug therapy
Inflammation Mediators
Interferon-gamma - metabolism
Interleukin-1beta - metabolism
Internal Medicine
Malondialdehyde - metabolism
Nitric Oxide - biosynthesis
Original Article
Oxidation-Reduction - drug effects
Oxidative Stress - drug effects
Pathology
Pharmacology/Toxicology
Proanthocyanidins - pharmacology
Quercetin - pharmacology
Rheumatology
Tumor Necrosis Factor-alpha - metabolism
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Summary:Phytochemical compounds are emerging as a new group of anti-inflammatory, antioxidant, and anti-cancer agents that help minimize toxicity in patients with pulmonary diseases. The goal of this study was to investigate the potential curative effects of Quercetin (QC), Damnacanthal (DAM), and Proanthocyanidine (PA) on inflammatory mediators and oxidative stress parameters and to examine the viability of the A549 cell line treated with benzo( a )pyrene (BaP) in vitro . The A549 cell line was treated with BaP, a BaP/QC combination, a BaP/DAM combination, and BaP/PA combination. Inflammatory markers, oxidative stress parameters, mRNA expression levels of apoptotic and antiapoptotic proteins, and cell viability were assessed, and the results were compared. There were higher levels of lactate dehydrogenase after BaP treatment of A549 cell lines. Interferon-γ level significantly decreased in the QC, DAM, and PA-treated group ( P  
ISSN:0360-3997
1573-2576
DOI:10.1007/s10753-015-0301-3