Loading…
Comparison of the Anti-inflammatory Effects of Proanthocyanidin, Quercetin, and Damnacanthal on Benzo(a)pyrene Exposed A549 Alveolar Cell Line
Phytochemical compounds are emerging as a new group of anti-inflammatory, antioxidant, and anti-cancer agents that help minimize toxicity in patients with pulmonary diseases. The goal of this study was to investigate the potential curative effects of Quercetin (QC), Damnacanthal (DAM), and Proanthoc...
Saved in:
| Published in: | Inflammation 2016-04, Vol.39 (2), p.744-751 |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c405t-f4f62b2e2985ae71de5f41cf1daed6396d1cedd2b74b4105f60f57d88fa055753 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c405t-f4f62b2e2985ae71de5f41cf1daed6396d1cedd2b74b4105f60f57d88fa055753 |
| container_end_page | 751 |
| container_issue | 2 |
| container_start_page | 744 |
| container_title | Inflammation |
| container_volume | 39 |
| creator | Günay, Ersin Celik, Sefa Sarinc-Ulasli, Sevinc Özyürek, Arzu Hazman, Ömer Günay, Sibel Özdemir, Mehmet Ünlü, Mehmet |
| description | Phytochemical compounds are emerging as a new group of anti-inflammatory, antioxidant, and anti-cancer agents that help minimize toxicity in patients with pulmonary diseases. The goal of this study was to investigate the potential curative effects of Quercetin (QC), Damnacanthal (DAM), and Proanthocyanidine (PA) on inflammatory mediators and oxidative stress parameters and to examine the viability of the A549 cell line treated with benzo(
a
)pyrene (BaP)
in vitro
. The A549 cell line was treated with BaP, a BaP/QC combination, a BaP/DAM combination, and BaP/PA combination. Inflammatory markers, oxidative stress parameters, mRNA expression levels of apoptotic and antiapoptotic proteins, and cell viability were assessed, and the results were compared. There were higher levels of lactate dehydrogenase after BaP treatment of A549 cell lines. Interferon-γ level significantly decreased in the QC, DAM, and PA-treated group (
P
|
| doi_str_mv | 10.1007/s10753-015-0301-3 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1780528709</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1780528709</sourcerecordid><originalsourceid>FETCH-LOGICAL-c405t-f4f62b2e2985ae71de5f41cf1daed6396d1cedd2b74b4105f60f57d88fa055753</originalsourceid><addsrcrecordid>eNp1kVFrFDEQx4Mo9lr9AL5IwJcWXJ0km83u4_U8beFABX0Ouc3EbtlN1mRXPD9EP7NZrhYRfMpAfvOfYX6EvGDwhgGot4mBkqIAJgsQwArxiKyYVKLgUlWPyQpEBYVoGnVCTlO6BYC6qcVTcsIrVSqu-IrcbcIwmtil4GlwdLpBuvZTV3Te9WYYzBTigW6dw3ZKC_ApBuOnm9AejO9s51_TzzPGFqelNN7Sd2bwpl0Y09Mceon-Vzg3F-Mhoke6_TmGhJauZdnQdf8DQ28i3WDf013n8Rl54kyf8Pn9e0a-vt9-2VwVu48frjfrXdGWIKfCla7ie468qaVBxSxKV7LWMWvQVqKpLGvRWr5X5b5kIF0FTipb186AlPlmZ-T8mDvG8H3GNOmhS23ewngMc9JM1SB5raDJ6Kt_0NswR5-3y5TKV2xUU2WKHak2hpQiOj3GbjDxoBnoRZY-ytJZll5kaZF7Xt4nz_sB7UPHHzsZ4Ecg5S__DeNfo_-b-hvFGp-v</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1777279796</pqid></control><display><type>article</type><title>Comparison of the Anti-inflammatory Effects of Proanthocyanidin, Quercetin, and Damnacanthal on Benzo(a)pyrene Exposed A549 Alveolar Cell Line</title><source>Springer Nature</source><creator>Günay, Ersin ; Celik, Sefa ; Sarinc-Ulasli, Sevinc ; Özyürek, Arzu ; Hazman, Ömer ; Günay, Sibel ; Özdemir, Mehmet ; Ünlü, Mehmet</creator><creatorcontrib>Günay, Ersin ; Celik, Sefa ; Sarinc-Ulasli, Sevinc ; Özyürek, Arzu ; Hazman, Ömer ; Günay, Sibel ; Özdemir, Mehmet ; Ünlü, Mehmet</creatorcontrib><description>Phytochemical compounds are emerging as a new group of anti-inflammatory, antioxidant, and anti-cancer agents that help minimize toxicity in patients with pulmonary diseases. The goal of this study was to investigate the potential curative effects of Quercetin (QC), Damnacanthal (DAM), and Proanthocyanidine (PA) on inflammatory mediators and oxidative stress parameters and to examine the viability of the A549 cell line treated with benzo(
a
)pyrene (BaP)
in vitro
. The A549 cell line was treated with BaP, a BaP/QC combination, a BaP/DAM combination, and BaP/PA combination. Inflammatory markers, oxidative stress parameters, mRNA expression levels of apoptotic and antiapoptotic proteins, and cell viability were assessed, and the results were compared. There were higher levels of lactate dehydrogenase after BaP treatment of A549 cell lines. Interferon-γ level significantly decreased in the QC, DAM, and PA-treated group (
P
< 0.001). IL-1β and TNF-α levels significantly decreased after PA and QC treatments (
P
< 0.001). Some of the oxidative stress markers (NO, MDA, TOS) and OSI decreased, while antioxidant (GSH) levels increased after treatment with QC, DAM, and PA. The QC and DAM treatments profoundly upregulated apoptotic gene expression and downregulated antiapoptotic gene expression. Viability of QC, DAM, and PA-treated cells was found to be significantly higher in comparison to the control and BaP-treated groups (
p
< 0.001). Our results revealed that A549 cell lines treated with BaP-stimulated necrosis produced higher level of inflammatory cytokines and oxidative stress parameters. Treatments with PA, QC, and DAM reduced inflammatory response induced by BaP exposure.</description><identifier>ISSN: 0360-3997</identifier><identifier>EISSN: 1573-2576</identifier><identifier>DOI: 10.1007/s10753-015-0301-3</identifier><identifier>PMID: 26747272</identifier><identifier>CODEN: INFLD4</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>A549 Cells ; Alveolar Epithelial Cells - immunology ; Alveolar Epithelial Cells - pathology ; Anthraquinones - pharmacology ; Anti-Inflammatory Agents - pharmacology ; Antioxidants - pharmacology ; Apoptosis - drug effects ; Benzo(a)pyrene ; Biomedical and Life Sciences ; Biomedicine ; Cell Line, Tumor ; Cell Survival - drug effects ; Cytokines - biosynthesis ; Glutathione - metabolism ; Humans ; Immunology ; Inflammation - drug therapy ; Inflammation Mediators ; Interferon-gamma - metabolism ; Interleukin-1beta - metabolism ; Internal Medicine ; Malondialdehyde - metabolism ; Nitric Oxide - biosynthesis ; Original Article ; Oxidation-Reduction - drug effects ; Oxidative Stress - drug effects ; Pathology ; Pharmacology/Toxicology ; Proanthocyanidins - pharmacology ; Quercetin - pharmacology ; Rheumatology ; Tumor Necrosis Factor-alpha - metabolism</subject><ispartof>Inflammation, 2016-04, Vol.39 (2), p.744-751</ispartof><rights>Springer Science+Business Media New York 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-f4f62b2e2985ae71de5f41cf1daed6396d1cedd2b74b4105f60f57d88fa055753</citedby><cites>FETCH-LOGICAL-c405t-f4f62b2e2985ae71de5f41cf1daed6396d1cedd2b74b4105f60f57d88fa055753</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26747272$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Günay, Ersin</creatorcontrib><creatorcontrib>Celik, Sefa</creatorcontrib><creatorcontrib>Sarinc-Ulasli, Sevinc</creatorcontrib><creatorcontrib>Özyürek, Arzu</creatorcontrib><creatorcontrib>Hazman, Ömer</creatorcontrib><creatorcontrib>Günay, Sibel</creatorcontrib><creatorcontrib>Özdemir, Mehmet</creatorcontrib><creatorcontrib>Ünlü, Mehmet</creatorcontrib><title>Comparison of the Anti-inflammatory Effects of Proanthocyanidin, Quercetin, and Damnacanthal on Benzo(a)pyrene Exposed A549 Alveolar Cell Line</title><title>Inflammation</title><addtitle>Inflammation</addtitle><addtitle>Inflammation</addtitle><description>Phytochemical compounds are emerging as a new group of anti-inflammatory, antioxidant, and anti-cancer agents that help minimize toxicity in patients with pulmonary diseases. The goal of this study was to investigate the potential curative effects of Quercetin (QC), Damnacanthal (DAM), and Proanthocyanidine (PA) on inflammatory mediators and oxidative stress parameters and to examine the viability of the A549 cell line treated with benzo(
a
)pyrene (BaP)
in vitro
. The A549 cell line was treated with BaP, a BaP/QC combination, a BaP/DAM combination, and BaP/PA combination. Inflammatory markers, oxidative stress parameters, mRNA expression levels of apoptotic and antiapoptotic proteins, and cell viability were assessed, and the results were compared. There were higher levels of lactate dehydrogenase after BaP treatment of A549 cell lines. Interferon-γ level significantly decreased in the QC, DAM, and PA-treated group (
P
< 0.001). IL-1β and TNF-α levels significantly decreased after PA and QC treatments (
P
< 0.001). Some of the oxidative stress markers (NO, MDA, TOS) and OSI decreased, while antioxidant (GSH) levels increased after treatment with QC, DAM, and PA. The QC and DAM treatments profoundly upregulated apoptotic gene expression and downregulated antiapoptotic gene expression. Viability of QC, DAM, and PA-treated cells was found to be significantly higher in comparison to the control and BaP-treated groups (
p
< 0.001). Our results revealed that A549 cell lines treated with BaP-stimulated necrosis produced higher level of inflammatory cytokines and oxidative stress parameters. Treatments with PA, QC, and DAM reduced inflammatory response induced by BaP exposure.</description><subject>A549 Cells</subject><subject>Alveolar Epithelial Cells - immunology</subject><subject>Alveolar Epithelial Cells - pathology</subject><subject>Anthraquinones - pharmacology</subject><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>Antioxidants - pharmacology</subject><subject>Apoptosis - drug effects</subject><subject>Benzo(a)pyrene</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cell Line, Tumor</subject><subject>Cell Survival - drug effects</subject><subject>Cytokines - biosynthesis</subject><subject>Glutathione - metabolism</subject><subject>Humans</subject><subject>Immunology</subject><subject>Inflammation - drug therapy</subject><subject>Inflammation Mediators</subject><subject>Interferon-gamma - metabolism</subject><subject>Interleukin-1beta - metabolism</subject><subject>Internal Medicine</subject><subject>Malondialdehyde - metabolism</subject><subject>Nitric Oxide - biosynthesis</subject><subject>Original Article</subject><subject>Oxidation-Reduction - drug effects</subject><subject>Oxidative Stress - drug effects</subject><subject>Pathology</subject><subject>Pharmacology/Toxicology</subject><subject>Proanthocyanidins - pharmacology</subject><subject>Quercetin - pharmacology</subject><subject>Rheumatology</subject><subject>Tumor Necrosis Factor-alpha - metabolism</subject><issn>0360-3997</issn><issn>1573-2576</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNp1kVFrFDEQx4Mo9lr9AL5IwJcWXJ0km83u4_U8beFABX0Ouc3EbtlN1mRXPD9EP7NZrhYRfMpAfvOfYX6EvGDwhgGot4mBkqIAJgsQwArxiKyYVKLgUlWPyQpEBYVoGnVCTlO6BYC6qcVTcsIrVSqu-IrcbcIwmtil4GlwdLpBuvZTV3Te9WYYzBTigW6dw3ZKC_ApBuOnm9AejO9s51_TzzPGFqelNN7Sd2bwpl0Y09Mceon-Vzg3F-Mhoke6_TmGhJauZdnQdf8DQ28i3WDf013n8Rl54kyf8Pn9e0a-vt9-2VwVu48frjfrXdGWIKfCla7ie468qaVBxSxKV7LWMWvQVqKpLGvRWr5X5b5kIF0FTipb186AlPlmZ-T8mDvG8H3GNOmhS23ewngMc9JM1SB5raDJ6Kt_0NswR5-3y5TKV2xUU2WKHak2hpQiOj3GbjDxoBnoRZY-ytJZll5kaZF7Xt4nz_sB7UPHHzsZ4Ecg5S__DeNfo_-b-hvFGp-v</recordid><startdate>20160401</startdate><enddate>20160401</enddate><creator>Günay, Ersin</creator><creator>Celik, Sefa</creator><creator>Sarinc-Ulasli, Sevinc</creator><creator>Özyürek, Arzu</creator><creator>Hazman, Ömer</creator><creator>Günay, Sibel</creator><creator>Özdemir, Mehmet</creator><creator>Ünlü, Mehmet</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20160401</creationdate><title>Comparison of the Anti-inflammatory Effects of Proanthocyanidin, Quercetin, and Damnacanthal on Benzo(a)pyrene Exposed A549 Alveolar Cell Line</title><author>Günay, Ersin ; Celik, Sefa ; Sarinc-Ulasli, Sevinc ; Özyürek, Arzu ; Hazman, Ömer ; Günay, Sibel ; Özdemir, Mehmet ; Ünlü, Mehmet</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-f4f62b2e2985ae71de5f41cf1daed6396d1cedd2b74b4105f60f57d88fa055753</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>A549 Cells</topic><topic>Alveolar Epithelial Cells - immunology</topic><topic>Alveolar Epithelial Cells - pathology</topic><topic>Anthraquinones - pharmacology</topic><topic>Anti-Inflammatory Agents - pharmacology</topic><topic>Antioxidants - pharmacology</topic><topic>Apoptosis - drug effects</topic><topic>Benzo(a)pyrene</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cell Line, Tumor</topic><topic>Cell Survival - drug effects</topic><topic>Cytokines - biosynthesis</topic><topic>Glutathione - metabolism</topic><topic>Humans</topic><topic>Immunology</topic><topic>Inflammation - drug therapy</topic><topic>Inflammation Mediators</topic><topic>Interferon-gamma - metabolism</topic><topic>Interleukin-1beta - metabolism</topic><topic>Internal Medicine</topic><topic>Malondialdehyde - metabolism</topic><topic>Nitric Oxide - biosynthesis</topic><topic>Original Article</topic><topic>Oxidation-Reduction - drug effects</topic><topic>Oxidative Stress - drug effects</topic><topic>Pathology</topic><topic>Pharmacology/Toxicology</topic><topic>Proanthocyanidins - pharmacology</topic><topic>Quercetin - pharmacology</topic><topic>Rheumatology</topic><topic>Tumor Necrosis Factor-alpha - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Günay, Ersin</creatorcontrib><creatorcontrib>Celik, Sefa</creatorcontrib><creatorcontrib>Sarinc-Ulasli, Sevinc</creatorcontrib><creatorcontrib>Özyürek, Arzu</creatorcontrib><creatorcontrib>Hazman, Ömer</creatorcontrib><creatorcontrib>Günay, Sibel</creatorcontrib><creatorcontrib>Özdemir, Mehmet</creatorcontrib><creatorcontrib>Ünlü, Mehmet</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Inflammation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Günay, Ersin</au><au>Celik, Sefa</au><au>Sarinc-Ulasli, Sevinc</au><au>Özyürek, Arzu</au><au>Hazman, Ömer</au><au>Günay, Sibel</au><au>Özdemir, Mehmet</au><au>Ünlü, Mehmet</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of the Anti-inflammatory Effects of Proanthocyanidin, Quercetin, and Damnacanthal on Benzo(a)pyrene Exposed A549 Alveolar Cell Line</atitle><jtitle>Inflammation</jtitle><stitle>Inflammation</stitle><addtitle>Inflammation</addtitle><date>2016-04-01</date><risdate>2016</risdate><volume>39</volume><issue>2</issue><spage>744</spage><epage>751</epage><pages>744-751</pages><issn>0360-3997</issn><eissn>1573-2576</eissn><coden>INFLD4</coden><abstract>Phytochemical compounds are emerging as a new group of anti-inflammatory, antioxidant, and anti-cancer agents that help minimize toxicity in patients with pulmonary diseases. The goal of this study was to investigate the potential curative effects of Quercetin (QC), Damnacanthal (DAM), and Proanthocyanidine (PA) on inflammatory mediators and oxidative stress parameters and to examine the viability of the A549 cell line treated with benzo(
a
)pyrene (BaP)
in vitro
. The A549 cell line was treated with BaP, a BaP/QC combination, a BaP/DAM combination, and BaP/PA combination. Inflammatory markers, oxidative stress parameters, mRNA expression levels of apoptotic and antiapoptotic proteins, and cell viability were assessed, and the results were compared. There were higher levels of lactate dehydrogenase after BaP treatment of A549 cell lines. Interferon-γ level significantly decreased in the QC, DAM, and PA-treated group (
P
< 0.001). IL-1β and TNF-α levels significantly decreased after PA and QC treatments (
P
< 0.001). Some of the oxidative stress markers (NO, MDA, TOS) and OSI decreased, while antioxidant (GSH) levels increased after treatment with QC, DAM, and PA. The QC and DAM treatments profoundly upregulated apoptotic gene expression and downregulated antiapoptotic gene expression. Viability of QC, DAM, and PA-treated cells was found to be significantly higher in comparison to the control and BaP-treated groups (
p
< 0.001). Our results revealed that A549 cell lines treated with BaP-stimulated necrosis produced higher level of inflammatory cytokines and oxidative stress parameters. Treatments with PA, QC, and DAM reduced inflammatory response induced by BaP exposure.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>26747272</pmid><doi>10.1007/s10753-015-0301-3</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0360-3997 |
| ispartof | Inflammation, 2016-04, Vol.39 (2), p.744-751 |
| issn | 0360-3997 1573-2576 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1780528709 |
| source | Springer Nature |
| subjects | A549 Cells Alveolar Epithelial Cells - immunology Alveolar Epithelial Cells - pathology Anthraquinones - pharmacology Anti-Inflammatory Agents - pharmacology Antioxidants - pharmacology Apoptosis - drug effects Benzo(a)pyrene Biomedical and Life Sciences Biomedicine Cell Line, Tumor Cell Survival - drug effects Cytokines - biosynthesis Glutathione - metabolism Humans Immunology Inflammation - drug therapy Inflammation Mediators Interferon-gamma - metabolism Interleukin-1beta - metabolism Internal Medicine Malondialdehyde - metabolism Nitric Oxide - biosynthesis Original Article Oxidation-Reduction - drug effects Oxidative Stress - drug effects Pathology Pharmacology/Toxicology Proanthocyanidins - pharmacology Quercetin - pharmacology Rheumatology Tumor Necrosis Factor-alpha - metabolism |
| title | Comparison of the Anti-inflammatory Effects of Proanthocyanidin, Quercetin, and Damnacanthal on Benzo(a)pyrene Exposed A549 Alveolar Cell Line |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T02%3A59%3A39IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Comparison%20of%20the%20Anti-inflammatory%20Effects%20of%20Proanthocyanidin,%20Quercetin,%20and%20Damnacanthal%20on%20Benzo(a)pyrene%20Exposed%20A549%20Alveolar%20Cell%20Line&rft.jtitle=Inflammation&rft.au=G%C3%BCnay,%20Ersin&rft.date=2016-04-01&rft.volume=39&rft.issue=2&rft.spage=744&rft.epage=751&rft.pages=744-751&rft.issn=0360-3997&rft.eissn=1573-2576&rft.coden=INFLD4&rft_id=info:doi/10.1007/s10753-015-0301-3&rft_dat=%3Cproquest_cross%3E1780528709%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c405t-f4f62b2e2985ae71de5f41cf1daed6396d1cedd2b74b4105f60f57d88fa055753%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1777279796&rft_id=info:pmid/26747272&rfr_iscdi=true |