Effect of discontinuation of antihypertensive medication on orthostatic hypotension in older persons with mild cognitive impairment: the DANTE Study Leiden

• Published in: Age and ageing 2016-03, Vol.45 (2), p.249-255
• Main Authors: Moonen, Justine E F, Foster-Dingley, Jessica C, de Ruijter, Wouter, van der Grond, Jeroen, de Craen, Anton J M, van der Mast, Roos C
• Format: Article
• Language: English
• Subjects: Aged; Aged, 80 and over; Ambiguity; Analysis; Antihypertensive Agents - administration & dosage; Antihypertensive Agents - adverse effects; Antihypertensive drugs; Blood pressure; Blood Pressure - drug effects; Cardiovascular diseases; Care and treatment; Clinical research; Clinical trials; Cognition; Cognitive ability; Cognitive Dysfunction - complications; Cognitive Dysfunction - diagnosis; Cognitive Dysfunction - psychology; Cognitive impairment; Discontinued; Drug Administration Schedule; Drug therapy; Drugs; Elderly; Elderly people; Female; Geriatric Assessment; Geriatrics; Gerontology; Health aspects; Humans; Hypertension; Hypertension - complications; Hypertension - diagnosis; Hypertension - drug therapy; Hypertension - physiopathology; Hypotension; Hypotension, Orthostatic - chemically induced; Hypotension, Orthostatic - diagnosis; Hypotension, Orthostatic - physiopathology; Hypotension, Orthostatic - prevention & control; Intention to Treat Analysis; Male; Motivation; Netherlands; Odds Ratio; Older people; Predictive Value of Tests; Recovery; Relative risks; Risk assessment; Risk Factors; Time Factors; Treatment Outcome
• ISSN: 0002-0729; 1468-2834
• DOI: 10.1093/ageing/afv199

the relationship between antihypertensive medication and orthostatic hypotension in older persons remains ambiguous, due to conflicting observational evidence and lack of data of clinical trials. to assess the effect of discontinuation of antihypertensive medication on orthostatic hypotension in older persons with mild cognitive impairment. a total of 162 participants with orthostatic hypotension were selected from the Discontinuation of Antihypertensive Treatment in Elderly people (DANTE) Study. This randomised clinical trial included community-dwelling participants aged ≥75 years, with mild cognitive impairment, using antihypertensive medication and without serious cardiovascular disease. Participants were randomised to discontinuation or continuation of antihypertensive treatment (ratio 1:1). Orthostatic hypotension was defined as a drop of at least 20 mmHg in systolic blood pressure and/or 10 mmHg in diastolic blood pressure on standing from a seated position. Outcome was the absence of orthostatic hypotension at 4-month follow-up. Relative risks (RR) were calculated by intention-to-treat and per-protocol analyses. at follow-up, according to intention-to-treat analyses, of the 86 persons assigned to discontinuation of antihypertensive medication, 43 (50%) were free from orthostatic hypotension, compared with 29 (38%) of the 76 persons assigned to continuation of medication [RR 1.31 (95% confidence interval (CI) 0.92-1.87); P = 0.13]. Per-protocol analysis showed that recovery from orthostatic hypotension was significantly higher in persons who completely discontinued all antihypertensive medication (61%) compared with the continuation group (38%) [RR 1.60 (95% CI 1.10-2.31); P = 0.01]. in older persons with mild cognitive impairment and orthostatic hypotension receiving antihypertensive medication, discontinuation of antihypertensive medication may increase the probability of recovery from orthostatic hypotension.