The Key Proteins of Dopaminergic Neurotransmission of Human Peripheral Blood Lymphocytes: Changed mRNA Level in Alcohol Dependence Syndrome

The expression of dopamine receptor ( DRD ), Nurr1 transcription factor ( NR4A2 ), and α-sinucleine ( SNCA ) genes in peripheral blood lymphocytes is evaluated. The results indicate that alcohol dependence is associated with high expression of SNCA and DRD4 (signifi cantly higher than in the control...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2015-12, Vol.160 (2), p.271-274
Main Authors: Taraskina, A. E., Grunina, M. N., Zabotina, A. M. R., Nasyrova, F., Ivanov, M. V., Krupitsky, E. M., Schwartzman, A. L.
Format: Article
Language:English
Subjects:
Adult
Alcoholism
Alcoholism - genetics
Alcoholism - metabolism
Antipsychotic drugs
Biomedical and Life Sciences
Biomedicine
Cell Biology
Dopamine receptors
Female
Gene expression
Humans
Internal Medicine
Laboratory Medicine
Lymphocytes
Lymphocytes - metabolism
Male
Messenger RNA
Middle Aged
Pathology
Proteins
Receptors, Dopamine - genetics
Receptors, Dopamine - metabolism
Receptors, Dopamine D3 - genetics
Receptors, Dopamine D3 - metabolism
RNA, Messenger - genetics
RNA, Messenger - metabolism
Synaptic Transmission - genetics
Synaptic Transmission - physiology
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Summary:The expression of dopamine receptor ( DRD ), Nurr1 transcription factor ( NR4A2 ), and α-sinucleine ( SNCA ) genes in peripheral blood lymphocytes is evaluated. The results indicate that alcohol dependence is associated with high expression of SNCA and DRD4 (signifi cantly higher than in the control group) and is not associated with changes in the work of NR4A2 and DRD3 genes. The levels of DRD3 and DRD4 mRNA form a positive linear correlation ( p ≤0.05). The expression of SNCA and DRD4 genes can serve as an important peripheral marker of alcohol dependence development, which is essential for antipsychotic therapy.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-015-3147-7