Insecticidal rocaglamide derivatives from Aglaia spectabilis (Meliaceae)

Bark of Aglaia spectabilis collected on the island of Phu Quoc (Vietnam) yielded 11 insecticidal cyclopentatetrahydrobenzofurans of the rocaglamide type including four new natural products. Structure elucidation of the new compounds is described. All rocaglamide derivatives isolated exhibited strong...

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Bibliographic Details
Published in:Phytochemistry (Oxford) 2000-08, Vol.54 (8), p.731-736
Main Authors: Schneider, C, Bohnenstengel, F.I, Nugroho, B.W, Wray, V, Witte, L, Hung, P.D, Kiet, L.C, Proksch, P
Format: Article
Language:English
Subjects:
Aglaia spectabilis
Benzofurans
Benzofurans - chemistry
Benzofurans - isolation & purification
Biological and medical sciences
Chemical control
Control
Fundamental and applied biological sciences. Psychology
Insecticides - chemistry
Insecticides - isolation & purification
Meliaceae
Molecular Structure
Natural insecticides
Noctuidae
Phytopathology. Animal pests. Plant and forest protection
Protozoa. Invertebrates
rocaglamide
Rocaglamide derivatives
Rosales - chemistry
Spectrum Analysis
Spodoptera littoralis
Structure elucidation
Vietnam
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Summary:Bark of Aglaia spectabilis collected on the island of Phu Quoc (Vietnam) yielded 11 insecticidal cyclopentatetrahydrobenzofurans of the rocaglamide type including four new natural products. Structure elucidation of the new compounds is described. All rocaglamide derivatives isolated exhibited strong insecticidal activity towards neonate larvae of the polyphagous pest insect Spodoptera littoralis when incorporated into an artificial diet. LC 50 values varied from 0.8 to 80 ppm. The most active compounds isolated, methylrocaglate and C-3′ hydroxylmethylrocaglate, were similar with regard to their insecticidal activity to the well-known natural insecticide azadirachtin.
ISSN:0031-9422
1873-3700
DOI:10.1016/S0031-9422(00)00205-3