Additional pyrrolomycins from cultures of Streptomyces fumanus

Along with dioxapyrrolomycin (1), four new pyrrolomycin antibiotics, namely, pyrrolomycin G (3), pyrrolomycin H (4), pyrrolomycin I (5), and pyrrolomycin J (6), were produced in cultures of Streptomyces fumanus. Apart from dioxapyrrolomycin, pyrrolomycin G and pyrrolomycin H are the only other chira...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2005-02, Vol.68 (2), p.277-279
Main Authors: Charan, R.D, Schlingmann, G, Bernan, V.S, Feng, X, Carter, G.T
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - classification
Anti-Bacterial Agents - isolation & purification
Anti-Bacterial Agents - pharmacology
antibacterial properties
antibiotics
Antibiotics (antibacterial agents, antifungal agents)
Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents
Applied microbiology
Biological and medical sciences
chemical structure
dioxapyrrolomycin
Enterococcus faecium
Escherichia coli
Fundamental and applied biological sciences. Psychology
Microbial Sensitivity Tests
Microbiology
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
pyrroles
Pyrroles - chemistry
Pyrroles - isolation & purification
Pyrroles - pharmacology
pyrrolomycins
spectral analysis
Staphylococcus aureus
Streptomyces - chemistry
Streptomyces fumanus
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Summary:Along with dioxapyrrolomycin (1), four new pyrrolomycin antibiotics, namely, pyrrolomycin G (3), pyrrolomycin H (4), pyrrolomycin I (5), and pyrrolomycin J (6), were produced in cultures of Streptomyces fumanus. Apart from dioxapyrrolomycin, pyrrolomycin G and pyrrolomycin H are the only other chiral members of the pyrrolomycin family of antibiotics, and their absolute stereochemistry was deduced to be 13S. Here, we report the isolation, structure elucidation, and antimicrobial activity of these new pyrrolomycins.
ISSN:0163-3864
1520-6025
DOI:10.1021/np0496542