Intravenous amitraz poisoning

Amitraz, a derivative of dimethylformamidine, is an acariside and insecticide used to control parasites in animals. Amitraz inhibits monoamine oxidase and prostaglandin synthesis and is an alpha-2 adrenergic agonist. Xylene, a mixture of o-, m-, and p-dimethylbenzene, is widely used in industry. A 2...

Full description

Saved in:
Bibliographic Details
Published in:Clinical toxicology (Philadelphia, Pa.) Pa.), 2005-01, Vol.43 (2), p.113-116
Main Authors: Gursoy, Sinan, Kunt, Nur, Kaygusuz, Kenan, Kafali, Haluk
Format: Article
Language:English
Subjects:
Adrenergic alpha-Agonists - poisoning
Adult
Bradycardia - chemically induced
Bradycardia - drug therapy
Female
Humans
Hypotension - chemically induced
Hypotension - drug therapy
Injections, Intravenous
Insecticides - poisoning
Neurotoxicity Syndromes - etiology
Neurotoxicity Syndromes - therapy
Poisoning - blood
Poisoning - drug therapy
Suicide, Attempted
Time Factors
Toluidines - administration & dosage
Toluidines - poisoning
Xylenes - administration & dosage
Xylenes - poisoning
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Amitraz, a derivative of dimethylformamidine, is an acariside and insecticide used to control parasites in animals. Amitraz inhibits monoamine oxidase and prostaglandin synthesis and is an alpha-2 adrenergic agonist. Xylene, a mixture of o-, m-, and p-dimethylbenzene, is widely used in industry. A 22-year-old woman was poisoned by an intravenous injection of 5-6 mL of an amitraz formulation (amitraz 12.5% + xylene 57.5%). Clinical findings were coma (Glasgow coma score 3), respiratory depression, hypotension, bradycardia, hematuria, and edema and hyperemia at the injection site. Although her coma and other symptoms quickly resolved, as has been seen in oral and dermal amitraz poisoning, intoxication with higher doses occurring from intravenous injection may result in more serious problems.
ISSN:1556-3650
1556-9519
DOI:10.1081/CLT-50412