Cutting-Edge and Time-Honored Strategies for Stereoselective Construction of C–N Bonds in Total Synthesis

The main objective of this review is to provide a comprehensive survey of methods used for stereoselective construction of carbon–nitrogen bonds during the total synthesis of nitrogen-containing natural products that have appeared in the literature since 2000. The material is organized by specific r...

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Bibliographic Details
Published in:Chemical reviews 2016-04, Vol.116 (7), p.4441-4557
Main Authors: Mailyan, Artur K, Eickhoff, John A, Minakova, Anastasiia S, Gu, Zhenhua, Lu, Ping, Zakarian, Armen
Format: Article
Language:English
Subjects:
Biological Products - chemical synthesis
Biological Products - chemistry
Carbon
Carbon - chemistry
Chemical bonds
Molecular Conformation
Natural products
Nitrogen
Nitrogen - chemistry
Stereoisomerism
Time Factors
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Summary:The main objective of this review is to provide a comprehensive survey of methods used for stereoselective construction of carbon–nitrogen bonds during the total synthesis of nitrogen-containing natural products that have appeared in the literature since 2000. The material is organized by specific reaction in order of decreasing number of applications in natural product synthesis. About 800 total syntheses of natural products with stereogenic carbon–nitrogen bonds described since 2000 have been reviewed.
ISSN:0009-2665
1520-6890
DOI:10.1021/acs.chemrev.5b00712