The diagnostic accuracy of Sudoscan in Transthyretin Familial Amyloid Polyneuropathy

Highlights • Assessment of autonomic function is critical in the diagnosis of Transthyretin familial amyloid polyneuropathy (TTR-FAP). • Feet electrochemical skin conductance was a significant independent predictor for the presence of symptoms and autonomic dysfunction in TTR-FAP. • Sudoscan showed...

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Bibliographic Details
Published in:Clinical neurophysiology 2016-05, Vol.127 (5), p.2222-2227
Main Authors: Castro, José, Miranda, Bruno, Castro, Isabel, de Carvalho, Mamede, Conceição, Isabel
Format: Article
Language:English
Subjects:
Action Potentials - physiology
Adult
Amyloid Neuropathies, Familial - diagnosis
Amyloid Neuropathies, Familial - genetics
Amyloid Neuropathies, Familial - physiopathology
Autonomic Nervous System - physiopathology
Diagnosis
Electrodiagnosis - methods
Female
Foot - physiopathology
Galvanic Skin Response - physiology
Hand - physiopathology
Heterozygote
Humans
Male
Middle Aged
Neurology
Sensitivity and Specificity
Small fiber neuropathy
Sudomotor function
Sudoscan
Sural Nerve - physiopathology
Transthyretin familial amyloid polyneuropathy
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Summary:Highlights • Assessment of autonomic function is critical in the diagnosis of Transthyretin familial amyloid polyneuropathy (TTR-FAP). • Feet electrochemical skin conductance was a significant independent predictor for the presence of symptoms and autonomic dysfunction in TTR-FAP. • Sudoscan showed a good sensitivity and specificity in the early diagnosis of TTR-FAP.
ISSN:1388-2457
1872-8952
DOI:10.1016/j.clinph.2016.02.013