Immunoreactivity of cAMP response element binding protein is not altered in the post-mortem cerebral cortex or cerebellum of alcoholics

— We examined amounts of cAMP response element binding protein (CREB) and its phosphorylated form in post-mortem frontal and temporal cortices and cerebella from alcoholics and controls by immunoblotting. No significant differences were observed in the levels of these proteins in each brain region,...

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Bibliographic Details
Published in:Alcohol and alcoholism (Oxford) 2001-01, Vol.36 (1), p.70-74
Main Authors: Yamamoto, Megumi, Pohli, Sabine, Durany, Nuria, Ozawa, Hiroki, Saito, Toshikazu, Boissl, Karl W., Zöchling, Robert, Riederer, Peter, Böning, Jobst, Götz, Mario E.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Alcoholism
Alcoholism - metabolism
Alcoholism and acute alcohol poisoning
Biological and medical sciences
cAMP response element binding protein
Cerebellum - metabolism
Cerebral Cortex - metabolism
CREB protein
Cyclic AMP Response Element-Binding Protein - metabolism
Female
Humans
Male
Medical sciences
Middle Aged
Phosphorylation
Statistics, Nonparametric
Toxicology
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Summary:— We examined amounts of cAMP response element binding protein (CREB) and its phosphorylated form in post-mortem frontal and temporal cortices and cerebella from alcoholics and controls by immunoblotting. No significant differences were observed in the levels of these proteins in each brain region, suggesting that the assumed neuroadaptations to chronic ethanol intake may not be reflected by quantitative alterations of CREB in alcoholic brain.
ISSN:0735-0414
1464-3502
1464-3502
DOI:10.1093/alcalc/36.1.70