CpG Oligodeoxynucleotides Adsorbed onto Polylactide-Co-Glycolide Microparticles Improve the Immunogenicity and Protective Activity of the Licensed Anthrax Vaccine

To reduce the biothreat posed by anthrax, efforts are under way to improve the protection afforded by vaccination. This work examines the ability of immunostimulatory CpG oligodeoxynucleotides (ODN) adsorbed onto cationic polylactide-co-glycolide (PLG) microparticles (CpG ODN-PLG) to accelerate and...

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Bibliographic Details
Published in:Infection and Immunity 2005-02, Vol.73 (2), p.828-833
Main Authors: Xie, Hang, Gursel, Ihsan, Ivins, Bruce E, Singh, Manmohan, O'Hagan, Derek T, Ulmer, Jeffrey B, Klinman, Dennis M
Format: Article
Language:English
Subjects:
Animals
Anthrax - immunology
Anthrax - prevention & control
Anthrax Vaccines - immunology
Applied microbiology
Bacillus anthracis
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Male
Mice
Microbial Immunity and Vaccines
Microbiology
Microspheres
Oligodeoxyribonucleotides - immunology
Polyglactin 910
Time Factors
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
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Summary:To reduce the biothreat posed by anthrax, efforts are under way to improve the protection afforded by vaccination. This work examines the ability of immunostimulatory CpG oligodeoxynucleotides (ODN) adsorbed onto cationic polylactide-co-glycolide (PLG) microparticles (CpG ODN-PLG) to accelerate and boost the protective immunity elicited by Anthrax Vaccine Adsorbed (AVA, the licensed human anthrax vaccine). The results indicate that coadministering CpG ODN-PLG with AVA induces a stronger and faster immunoglobulin G response against the protective antigen of anthrax than AVA alone. Immunized mice were protected from lethal anthrax challenge within 1 week of vaccination with CpG ODN-PLG plus AVA, with the level of protection correlating with serum immunoglobulin G anti-protective antigen titers.
ISSN:0019-9567
1098-5522
DOI:10.1128/iai.73.2.828-833.2005