Effect of carboxymethylation on rheological and drug release characteristics of locust bean gum matrix tablets

• Published in: Carbohydrate polymers 2016-06, Vol.144, p.50-58
• Main Authors: Chakravorty, Amrita, Barman, Gouranga, Mukherjee, Sudipta, Sa, Biswanath
• Format: Article
• Language: English
• Subjects: Acetates - chemical synthesis; Acetates - chemistry; Alkylation; Carbon-13 Magnetic Resonance Spectroscopy; Carboxymethylation; Drug Liberation; Drug release; Fabaceae - chemistry; Galactans - chemical synthesis; Galactans - chemistry; Ibuprofen - chemistry; Locust bean gum; Mannans - chemical synthesis; Mannans - chemistry; Metronidazole - chemistry; Plant Gums - chemical synthesis; Plant Gums - chemistry; Rheology; Spectroscopy, Fourier Transform Infrared; Viscosity
• ISSN: 0144-8617; 1879-1344
• DOI: 10.1016/j.carbpol.2016.02.010

•Carboxymethylation of locust bean gum.•Changes in rheological properties.•Drug release from polysaccharide matrices.•Correlation of rheological changes with drug release. This study was undertaken to investigate correlation between the carboxymethylation-induced rheological changes and drug release characteristics of locust bean gum (LBG) matrix tablets. LBG was derivatized to carboxymethyl LBG (CMLBG) and characterized by 13C NMR, FTIR and elemental analyses. Rheological studies revealed that LBG, in contact with water, produced a strong elastic gel which swelled less due to lower penetration of water resulting in slower drug release. On the other hand, CMLBG formed a viscous polymer solution through which higher influx of water resulted in rapid swelling of the matrix and faster drug release. Although the release from a particular matrix was dependent on drugs’ solubilities, CMLBG matrix tablet produced faster release of all the drugs than LBG matrix tablets. In conclusion, rheological study appeared to be an useful tool to predict release of drugs from polysaccharide matrix tablets.