The impact of bone morphogenetic protein 4 (BMP4) on breast cancer metastasis in a mouse xenograft model

Highlights • First study to assess the direct impact of BMP4 on breast cancer metastasis. • BMP4 treatment resulted in a slightly accelerated metastasis formation. • BMP4-treated mice had more bone and less adrenal gland metastases compared to controls. • BMP4 did not cause any changes in the tumor...

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Bibliographic Details
Published in:Cancer letters 2016-06, Vol.375 (2), p.238-244
Main Authors: Ampuja, M, Alarmo, E.L, Owens, P, Havunen, R, Gorska, A.E, Moses, H.L, Kallioniemi, A
Format: Article
Language:English
Subjects:
Animals
Bioluminescence imaging
BMP4
Bone morphogenetic protein
Bone Morphogenetic Protein 4 - administration & dosage
Bone Morphogenetic Protein 4 - genetics
Bone Neoplasms - genetics
Bone Neoplasms - pathology
Bone Neoplasms - secondary
Breast cancer
Breast Neoplasms - genetics
Breast Neoplasms - pathology
Cell cycle
Cell Differentiation - drug effects
Cell growth
Cell Line, Tumor
Conflicts of interest
Disease Models, Animal
Female
Fibroblasts
Gene Expression Regulation, Neoplastic - drug effects
Growth factors
Hematology, Oncology and Palliative Medicine
Humans
In vivo metastasis model
Kinases
Metastasis
Mice
Neoplasm Metastasis
Plasmids
Proteins
Recombinant Proteins - administration & dosage
Recombinant Proteins - genetics
Tumors
Xenograft Model Antitumor Assays
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Summary:Highlights • First study to assess the direct impact of BMP4 on breast cancer metastasis. • BMP4 treatment resulted in a slightly accelerated metastasis formation. • BMP4-treated mice had more bone and less adrenal gland metastases compared to controls. • BMP4 did not cause any changes in the tumor or stroma characteristics. • The induction of bone metastases may have clinical relevance.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2016.03.008