Indole Synthesis via Cobalt(III)-Catalyzed Oxidative Coupling of N‑Arylureas and Internal Alkynes

A mild Co­(III)-catalyzed oxidative annulation of N-arylureas and internal alkynes has been developed. The use of less electrophilic ureas other than acetamides as directing groups is crucial for the reaction. A broad range of synthetically useful functional groups are compatible with this reaction,...

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Bibliographic Details
Published in:Organic letters 2016-04, Vol.18 (8), p.1776-1779
Main Authors: Zhang, Zhuo-Zhuo, Liu, Bin, Xu, Jing-Wen, Yan, Sheng-Yi, Shi, Bing-Feng
Format: Article
Language:English
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Summary:A mild Co­(III)-catalyzed oxidative annulation of N-arylureas and internal alkynes has been developed. The use of less electrophilic ureas other than acetamides as directing groups is crucial for the reaction. A broad range of synthetically useful functional groups are compatible with this reaction, thus providing a new opportunity for the synthesis of diverse indoles.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.6b00494