Splenic irradiation provides transient palliation for symptomatic splenomegaly associated with primary myelofibrosis: a report on 14 patients

We retrospectively analyzed the outcomes of 14 patients with primary myelofibrosis who were treated with splenic irradiation (SI) for symptomatic splenomegaly between January 2000 and December 2012 at 12 hospitals. Median age at the time of SI was 67 years (range 47–76). The median dose of radiation...

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Bibliographic Details
Published in:International journal of hematology 2016-04, Vol.103 (4), p.423-428
Main Authors: Kitanaka, Akira, Takenaka, Katsuto, Shide, Kotaro, Miyamoto, Toshihiro, Kondo, Tadakazu, Ozawa, Keiya, Kurokawa, Mineo, Akashi, Koichi, Shimoda, Kazuya
Format: Article
Language:English
Subjects:
Aged
Female
Hematology
Humans
Male
Medicine
Medicine & Public Health
Middle Aged
Oncology
Original Article
Patient Comfort
Primary Myelofibrosis - complications
Radiotherapy Dosage
Retrospective Studies
Spleen - pathology
Spleen - radiation effects
Splenomegaly - etiology
Splenomegaly - pathology
Splenomegaly - radiotherapy
Survival Analysis
Treatment Outcome
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Summary:We retrospectively analyzed the outcomes of 14 patients with primary myelofibrosis who were treated with splenic irradiation (SI) for symptomatic splenomegaly between January 2000 and December 2012 at 12 hospitals. Median age at the time of SI was 67 years (range 47–76). The median dose of radiation per course was 5 Gy, administered in a median of eight fractions. Spleen size was reduced in 93 % of patients, and persisted for a median of 2.2 months (range 0.1–13.8). Symptom relief occurred in 86 % of patients, and lasted for a median of 2.5 months (range 0.1–16.5). Although SI provided a high rate of palliation for patients with symptomatic splenomegaly, the responses were transient. Significant thrombopenia (
ISSN:0925-5710
1865-3774
DOI:10.1007/s12185-016-1940-3