Reliability and validity of an instrument for the assessment of bradykinesia

Abstract Bradykinesia is associated with reduced quality of life and medication non-compliance, and it may be a prodrome for schizophrenia. Therefore, screening/monitoring for subtle bradykinesia is of clinical and scientific importance. This study investigated the validity and reliability of such a...

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Bibliographic Details
Published in:Psychiatry research 2016-04, Vol.238, p.189-195
Main Authors: Mentzel, Thierry Q, Lieverse, Ritsaert, Levens, Amar, Mentzel, Charlotte L, Tenback, Diederik E, Bakker, P. Rob, Daanen, Hein A.M, van Harten, Peter N
Format: Article
Language:English
Subjects:
Adult
Aged
Antipsychotic-induced
Diagnostic techniques and procedures
Elbow - physiopathology
Exercise Test - methods
Extrapyramidal disorders
Female
Forearm - physiopathology
Humans
Hypokinesia - diagnosis
Leg - physiopathology
Male
Micro-electrical-mechanical systems
Middle Aged
Parkinsonism
Psychiatry
Psychotic Disorders - physiopathology
Regression Analysis
Reproducibility of findings
Reproducibility of Results
Schizophrenia and disorders with psychotic features
Walking
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Summary:Abstract Bradykinesia is associated with reduced quality of life and medication non-compliance, and it may be a prodrome for schizophrenia. Therefore, screening/monitoring for subtle bradykinesia is of clinical and scientific importance. This study investigated the validity and reliability of such an instrument. Included were 70 patients with psychotic disorders. Inertial sensors captured mean cycle duration, amplitude and velocity of four movement tasks: walking, elbow flexion/extension, forearm pronation/supination and leg agility. The concurrent validity with the Unified Parkinson's Disease Rating Scale (UPDRS) bradykinesia subscale was determined using regression analysis. Reliability was investigated with the intra-class correlation coefficient. The duration, amplitude and velocities of the four tasks measured by the instrument explained 67% of the variance on the UPDRS bradykinesia subscale. The instrument test-retest reliability was high. The instrument investigated in this study is a valid and reliable alternative to observer-rated scales. It is an ideal tool for monitoring bradykinesia as it requires little training and experience to achieve reliable results.
ISSN:0165-1781
1872-7123
DOI:10.1016/j.psychres.2016.02.011