Intestinal transplantation

Abstract Intestinal transplantation has now emerged as a lifesaving therapeutic option and standard of care for patients with irreversible intestinal failure. Improvement in survival over the years has justified expansion of the indications for intestinal transplantation beyond the original indicati...

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Bibliographic Details
Published in:Baillière's best practice & research. Clinical gastroenterology 2016-04, Vol.30 (2), p.319-335
Main Authors: Rege, Aparna, MD, Sudan, Debra, MD
Format: Article
Language:English
Subjects:
Abdomen
Adults
Biopsy
Congenital diseases
Endoscopy
Gastroenterology and Hepatology
Gastrointestinal Diseases - surgery
Graft Survival - physiology
Humans
Immunosuppression
Immunosuppressive Agents - therapeutic use
Infection
Infections
Intestinal and multi-visceral transplantation
Intestinal failure
Intestine, Small - transplantation
Liver
Liver diseases
Medical prognosis
Morbidity
Mortality
Motility
Nutrition
Organ Transplantation - methods
Organ Transplantation - mortality
Outcomes
Parenteral nutrition
Patient Selection
Pediatrics
Quality of Life
Rehabilitation
Rejection
Studies
Thrombosis
Transplants & implants
Tumors
Veins & arteries
Weaning
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Summary:Abstract Intestinal transplantation has now emerged as a lifesaving therapeutic option and standard of care for patients with irreversible intestinal failure. Improvement in survival over the years has justified expansion of the indications for intestinal transplantation beyond the original indications approved by Center for Medicare and Medicaid services. Management of patients with intestinal failure is complex and requires a multidisciplinary approach to accurately select candidates who would benefit from rehabilitation versus transplantation. Significant strides have been made in patient and graft survival with several advancements in the perioperative management through timely referral, improved patient selection, refinement in the surgical techniques and better understanding of the immunopathology of intestinal transplantation. The therapeutic efficacy of the procedure is well evident from continuous improvements in functional status, quality of life and cost-effectiveness of the procedure. This current review summarizes various aspects including current practices and evidence based recommendations of intestinal transplantation.
ISSN:1521-6918
1532-1916
DOI:10.1016/j.bpg.2016.02.010