Prognostic factors in male breast cancer: a population-based study

Prognostic factors in male breast cancer (MaBC) are controversial. The objective of this study was to analyze patient characteristics and prognostic factors in MaBC over the last decade. Using the Surveillance, Epidemiology, and End Results program, we extracted MaBC patients diagnosed between 2003...

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Bibliographic Details
Published in:Breast cancer research and treatment 2016-04, Vol.156 (3), p.539-548
Main Authors: Leone, José Pablo, Zwenger, Ariel Osvaldo, Iturbe, Julián, Leone, Julieta, Leone, Bernardo Amadeo, Vallejo, Carlos Teodoro, Bhargava, Rohit
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Analysis
Breast cancer
Breast Neoplasms, Male - epidemiology
Breast Neoplasms, Male - metabolism
Breast Neoplasms, Male - pathology
Cancer research
Cancer therapies
Epidemiology
Humans
Kaplan-Meier Estimate
Male
Males
Medical prognosis
Medicine
Medicine & Public Health
Middle Aged
Neoplasm Grading
Oncology
Prognosis
Receptors, Estrogen - metabolism
Risk Factors
SEER Program
Studies
Young Adult
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Summary:Prognostic factors in male breast cancer (MaBC) are controversial. The objective of this study was to analyze patient characteristics and prognostic factors in MaBC over the last decade. Using the Surveillance, Epidemiology, and End Results program, we extracted MaBC patients diagnosed between 2003 and 2012. Patient characteristics were compared between tumor grades. We conducted univariate and multivariate analyses to determine the effects of each prognostic variable on overall survival (OS). The study included 2992 patients. The majority had ductal (85 %), ER-positive (95.1 %), and PR-positive (86 %) breast cancer; however, only 12.4 % had grade I tumors. Stage I and II disease represented 73 % of cases. There was a significant association between grade III/IV tumors with ductal histology, ER and PR negativity, advanced stage, receipt of mastectomy and radiotherapy, and breast cancer death (all P  
ISSN:0167-6806
1573-7217
DOI:10.1007/s10549-016-3768-1