Dependence of diameters and oxygen saturation of retinal vessels on visual field damage and age in primary open‐angle glaucoma

Purpose To investigate the interrelationship between the oxygen supply of the retina and its regulation with the severity of primary open‐angle glaucoma (POAG). Methods Central retinal artery (CRAE) and vein (CRVE) diameters and oxygen saturation of peripapillary retinal vessels in 41 patients suffe...

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Published in:Acta ophthalmologica (Oxford, England) England), 2016-05, Vol.94 (3), p.276-281
Main Authors: Ramm, Lisa, Jentsch, Susanne, Peters, Sven, Sauer, Lydia, Augsten, Regine, Hammer, Martin
Format: Article
Language:English
Subjects:
Aged
Antihypertensive Agents - therapeutic use
Female
Glaucoma, Open-Angle - drug therapy
Glaucoma, Open-Angle - physiopathology
Humans
layer thickness
Male
Middle Aged
Nerve Fibers - pathology
neuro‐retinal rim area
Ophthalmology
Oxygen - blood
Photic Stimulation
primary open angle glaucoma
Retinal Ganglion Cells - pathology
retinal nerve fiber
retinal oxygen saturation
Retinal Vessels - pathology
Tomography, Optical Coherence
Vision Disorders - physiopathology
Visual Field Tests
Visual Fields - physiology
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Summary:Purpose To investigate the interrelationship between the oxygen supply of the retina and its regulation with the severity of primary open‐angle glaucoma (POAG). Methods Central retinal artery (CRAE) and vein (CRVE) diameters and oxygen saturation of peripapillary retinal vessels in 41 patients suffering from POAG (64.1 ± 12.9 years) and 40 healthy volunteers (63.6 ± 14.1 years) were measured using the retinal vessel analyzer. All measures were taken before and during flicker light stimulation. The mean retinal nerve fiber layer thickness (RNFLT) was determined by OCT and the visual field mean defect (MD) was identified using perimetry. Results In glaucoma patients, CRAE (r = −0.48 p = 0.002) and CRVE (r = −0.394 p = 0.014) at baseline were inversely related to MD, while arterial and venous oxygen saturation showed no significant dependence on the severity of the damage. However, the flicker light‐induced change in arterio‐venous difference in oxygen saturation was correlated with the MD (r = 0.358 p = 0.027). The diameters of arteries and veins at baseline decreased with reduction of the mean RNFLT (arteries: r = 0.718 p 
ISSN:1755-375X
1755-3768
DOI:10.1111/aos.12727