Boronic Acid-Functionalized Particles with Flexible Three-Dimensional Polymer Branch for Highly Specific Recognition of Glycoproteins

A novel organic–inorganic hybrid particle with high hydrophilicity three-dimensional boronic acid functional polymer branches was facilely synthesized through thiol–ene surface-initiated click reaction, by which the target glycoprotein could be captured selectively in the 5000-fold disrupting protei...

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Bibliographic Details
Published in:ACS applied materials & interfaces 2016-04, Vol.8 (15), p.9552-9556
Main Authors: Liu, Jianxi, Yang, Kaiguang, Shao, Wenya, Qu, Yanyan, Li, Senwu, Wu, Qi, Zhang, Lihua, Zhang, Yukui
Format: Article
Language:English
Subjects:
Animals
Boronic Acids - chemistry
Cattle
Chickens
Electrophoresis, Polyacrylamide Gel
Glycoproteins - metabolism
Horseradish Peroxidase - metabolism
Polymers - chemistry
Serum Albumin, Bovine - metabolism
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
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Summary:A novel organic–inorganic hybrid particle with high hydrophilicity three-dimensional boronic acid functional polymer branches was facilely synthesized through thiol–ene surface-initiated click reaction, by which the target glycoprotein could be captured selectively in the 5000-fold disrupting protein. This highest selectivity ever reported demonstrated that this boronic acid functionalized particle exhibited great potential in the recognition of cis-diol-containing biomolecules, including the glycoproteins.
ISSN:1944-8244
1944-8252
DOI:10.1021/acsami.6b01829